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1986 2
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1996 3
1998 3
2001 1
2003 2
2004 3
2005 5
2006 2
2007 4
2008 6
2009 2
2010 6
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2012 3
2013 5
2014 6
2015 4
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2017 3
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105 results

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Page 1
The stress granule protein G3BP1 alleviates spinocerebellar ataxia-associated deficits.
Koppenol R, Conceição A, Afonso IT, Afonso-Reis R, Costa RG, Tomé S, Teixeira D, da Silva JP, Côdesso JM, Brito DVC, Mendonça L, Marcelo A, Pereira de Almeida L, Matos CA, Nóbrega C. Koppenol R, et al. Brain. 2023 Jun 1;146(6):2346-2363. doi: 10.1093/brain/awac473. Brain. 2023. PMID: 36511898 Free PMC article.
We evaluated the ability of GTPase-activating protein-binding protein 1 (G3BP1), an RNA-binding protein involved in RNA metabolism regulation and stress responses, to counteract SCA2 and SCA3 pathology, using both in vitro and in vivo disease models. Our results indicate t …
We evaluated the ability of GTPase-activating protein-binding protein 1 (G3BP1), an RNA-binding protein involved in RNA metabolism regulatio …
Annona Genus: Traditional Uses, Phytochemistry and Biological Activities.
Leite DOD, de F A Nonato C, Camilo CJ, de Carvalho NKG, da Nobrega MGLA, Pereira RC, da Costa JGM. Leite DOD, et al. Curr Pharm Des. 2020;26(33):4056-4091. doi: 10.2174/1381612826666200325094422. Curr Pharm Des. 2020. PMID: 32209036 Review.
Ethnobotanical studies provide information regarding the plant part and the preparation method being used, while scientific studies such as in vitro, in vivo, and clinical tests can provide evidence supporting ethnopharmacological reports, directing studies towards the iso …
Ethnobotanical studies provide information regarding the plant part and the preparation method being used, while scientific studies such as …
Spermatogonial Stem Cells in Fish: Characterization, Isolation, Enrichment, and Recent Advances of In Vitro Culture Systems.
Xie X, Nóbrega R, Pšenička M. Xie X, et al. Biomolecules. 2020 Apr 22;10(4):644. doi: 10.3390/biom10040644. Biomolecules. 2020. PMID: 32331205 Free PMC article. Review.
To provide insight into techniques and research related to SSCs, we review available protocols and advances in enriching undifferentiated spermatogonia based on their unique physiochemical and biochemical properties, such as size, density, and differential expression of specific …
To provide insight into techniques and research related to SSCs, we review available protocols and advances in enriching undifferentiated sp …
In vitro assessment of dental erosion caused by clear aligners.
Nobrega C, Nunes GP, de Paiva Buischi Y, Kajimoto NC, Delbem ACB. Nobrega C, et al. J Mech Behav Biomed Mater. 2024 Apr;152:106390. doi: 10.1016/j.jmbbm.2024.106390. Epub 2024 Jan 14. J Mech Behav Biomed Mater. 2024. PMID: 38277909
The primary objective of this in vitro study was to investigate the erosive potential of enamel under the use of clear aligners (CA), by simulating in vivo conditions experienced by patients who do not remove their CA during the consumption of acidic beverages. ...
The primary objective of this in vitro study was to investigate the erosive potential of enamel under the use of clear aligners (CA), …
The synthetic cathinone α-pyrrolidinovalerophenone (α-PVP): pharmacokinetic and pharmacodynamic clinical and forensic aspects.
Nóbrega L, Dinis-Oliveira RJ. Nóbrega L, et al. Drug Metab Rev. 2018 May;50(2):125-139. doi: 10.1080/03602532.2018.1448867. Epub 2018 Mar 14. Drug Metab Rev. 2018. PMID: 29540067 Review.
This work aims to review the state-of-the-art regarding chemical, molecular pharmacology, and in vitro and in vivo data on toxicokinetics of the potent synthetic cathinone alpha-pyrrolidinovalerophenone (alpha-PVP or flakka or zombie drug). ...
This work aims to review the state-of-the-art regarding chemical, molecular pharmacology, and in vitro and in vivo data on toxicokine …
In vitro scan for enhancers at the TCF7L2 locus.
Savic D, Park SY, Bailey KA, Bell GI, Nobrega MA. Savic D, et al. Diabetologia. 2013 Jan;56(1):121-5. doi: 10.1007/s00125-012-2730-y. Epub 2012 Sep 26. Diabetologia. 2013. PMID: 23011354 Free PMC article.
Several studies point to a similar mechanism at the transcription factor 7-like 2 (TCF7L2) GWAS locus for type 2 diabetes. To address this possibility, we carried out an in vitro scan of this diabetes-associated locus to fine-map cis-regulatory sequences within this genomi …
Several studies point to a similar mechanism at the transcription factor 7-like 2 (TCF7L2) GWAS locus for type 2 diabetes. To address this p …
Altered Cogs of the Clock: Insights into the Embryonic Etiology of Spondylocostal Dysostosis.
Nóbrega A, Maia-Fernandes AC, Andrade RP. Nóbrega A, et al. J Dev Biol. 2021 Jan 29;9(1):5. doi: 10.3390/jdb9010005. J Dev Biol. 2021. PMID: 33572886 Free PMC article. Review.
Evidence of an environmental contribution to the severity of the disease is discussed. Finally, a brief reference is made to emerging in vitro models of human somitogenesis which are being employed to model the molecular and cellular events occurring in SCDO. ...
Evidence of an environmental contribution to the severity of the disease is discussed. Finally, a brief reference is made to emerging in …
Paracrine/autocrine control of spermatogenesis by gonadotropin-inhibitory hormone.
Fallah HP, Tovo-Neto A, Yeung EC, Nóbrega RH, Habibi HR. Fallah HP, et al. Mol Cell Endocrinol. 2019 Jul 15;492:110440. doi: 10.1016/j.mce.2019.04.020. Epub 2019 Apr 29. Mol Cell Endocrinol. 2019. PMID: 31048005
Here, we investigated direct action of zebrafish gonadotropin-inhibitory hormone (zGnih) which is expressed in the testis, on spermatogenesis in zebrafish, in vitro. Treatment with zGnih at the lower doses (10 and 100 nM) inhibited gonadotropin-induced spermatids/spermatoz …
Here, we investigated direct action of zebrafish gonadotropin-inhibitory hormone (zGnih) which is expressed in the testis, on spermatogenesi …
Cylindrospermopsin Disrupts Estrous Cycle and Increases Spermatogenesis in Mice.
de Moraes ACN, Caires FO, Imperio GE, Nóbrega RH, Ortiga-Carvalho TM, de Magalhães VF. de Moraes ACN, et al. Reprod Sci. 2022 Oct;29(10):2876-2884. doi: 10.1007/s43032-022-00907-0. Epub 2022 Mar 7. Reprod Sci. 2022. PMID: 35257354
Cylindrospermopsin (CYN) is a water-soluble cyanotoxin that has been linked to several cases of poisoning in the world. In vitro studies have shown that CYN acts as an endocrine disruptor by inhibiting progesterone synthesis in primary cell cultures of women, showing estro …
Cylindrospermopsin (CYN) is a water-soluble cyanotoxin that has been linked to several cases of poisoning in the world. In vitro stud …
Plant Extracts Loaded in Nanostructured Drug Delivery Systems for Treating Parasitic and Antimicrobial Diseases.
Gondim BLC, Oshiro-Júnior JA, Fernanandes FHA, Nóbrega FP, Castellano LRC, Medeiros ACD. Gondim BLC, et al. Curr Pharm Des. 2019;25(14):1604-1615. doi: 10.2174/1381612825666190628153755. Curr Pharm Des. 2019. PMID: 31264539 Review.
In this review, we present the most recent data on NDDSs using plant extracts and report results obtained from studies related to in vitro and in vivo biological activities....
In this review, we present the most recent data on NDDSs using plant extracts and report results obtained from studies related to in vitr …
105 results