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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2003 1
2004 6
2005 7
2006 8
2007 22
2008 33
2009 35
2010 55
2011 60
2012 73
2013 82
2014 100
2015 130
2016 133
2017 119
2018 131
2019 139
2020 96
2021 99
2022 86
2023 79
2024 35

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1,344 results

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Page 1
Delivery of RNA Therapeutics: The Great Endosomal Escape!
Dowdy SF, Setten RL, Cui XS, Jadhav SG. Dowdy SF, et al. Nucleic Acid Ther. 2022 Oct;32(5):361-368. doi: 10.1089/nat.2022.0004. Epub 2022 May 24. Nucleic Acid Ther. 2022. PMID: 35612432 Free PMC article. Review.
RNA therapeutic activity is mechanistically driven by Watson-Crick base pairing to the target gene RNA without the requirement of prior knowledge of the protein structure, function, or cellular location. ...Unlike small-molecule therapeutics that are designed …
RNA therapeutic activity is mechanistically driven by Watson-Crick base pairing to the target gene RNA without the requirement …
Disorders and roles of tsRNA, snoRNA, snRNA and piRNA in cancer.
Xiao L, Wang J, Ju S, Cui M, Jing R. Xiao L, et al. J Med Genet. 2022 Jul;59(7):623-631. doi: 10.1136/jmedgenet-2021-108327. Epub 2022 Feb 10. J Med Genet. 2022. PMID: 35145038 Review.
Most small non-coding RNAs (sncRNAs) with regulatory functions are encoded by majority sequences in the human genome, and the emergence of high-throughput sequencing technology has greatly expanded our understanding of sncRNAs. sncRNAs are composed of a variety of RNAs, in …
Most small non-coding RNAs (sncRNAs) with regulatory functions are encoded by majority sequences in the human genome, and the emergen …
SENP1 promotes hypoxia-induced cancer stemness by HIF-1α deSUMOylation and SENP1/HIF-1α positive feedback loop.
Cui CP, Wong CC, Kai AK, Ho DW, Lau EY, Tsui YM, Chan LK, Cheung TT, Chok KS, Chan ACY, Lo RC, Lee JM, Lee TK, Ng IOL. Cui CP, et al. Gut. 2017 Dec;66(12):2149-2159. doi: 10.1136/gutjnl-2016-313264. Epub 2017 Mar 3. Gut. 2017. PMID: 28258134 Free PMC article.
DESIGN: HCC cancer stemness was analysed by self-renewal ability, chemoresistance, expression of stemness-related genes and cancer stem cell (CSC) marker-positive cell population. Specific small ubiquitin-like modifier (SUMO) proteases 1 (SENP1) mRNA level was examined wit …
DESIGN: HCC cancer stemness was analysed by self-renewal ability, chemoresistance, expression of stemness-related genes and cancer stem cell …
Alpha-kinase1 promotes tubular injury and interstitial inflammation in diabetic nephropathy by canonical pyroptosis pathway.
Cui X, Li Y, Yuan S, Huang Y, Chen X, Han Y, Liu Z, Li Z, Xiao Y, Wang Y, Sun L, Liu H, Zhu X. Cui X, et al. Biol Res. 2023 Feb 2;56(1):5. doi: 10.1186/s40659-023-00416-7. Biol Res. 2023. PMID: 36732854 Free PMC article.
HK-2 cells treated with high-glucose (HG) served as an in vitro model. ALPK1 small interfering RNA (siRNA) was transfected into HK-2 cells to down-regulate ALPK1. ...
HK-2 cells treated with high-glucose (HG) served as an in vitro model. ALPK1 small interfering RNA (siRNA) was transfec …
ZNF281 drives hepatocyte senescence in alcoholic liver disease by reducing HK2-stabilized PINK1/Parkin-mediated mitophagy.
Lu C, Ge T, Shao Y, Cui W, Li Z, Xu W, Bao X. Lu C, et al. Cell Prolif. 2023 Mar;56(3):e13378. doi: 10.1111/cpr.13378. Epub 2022 Dec 14. Cell Prolif. 2023. PMID: 36514923 Free PMC article.
Systematic ZNF281 knockdown by adeno-associated virus encoding ZNF281 shRNA protected mice from alcohol feeding-caused hepatocyte injury and senescence. ...
Systematic ZNF281 knockdown by adeno-associated virus encoding ZNF281 shRNA protected mice from alcohol feeding-caused hepatocyte inj …
Epigenetic synthetic lethality approaches in cancer therapy.
Yang H, Cui W, Wang L. Yang H, et al. Clin Epigenetics. 2019 Oct 7;11(1):136. doi: 10.1186/s13148-019-0734-x. Clin Epigenetics. 2019. PMID: 31590683 Free PMC article. Review.
In recent years, a variety of epigenetic regulators have been discovered, and corresponding small molecule inhibitors have been developed, but their efficacy in solid tumors is generally poor. With the introduction of the first synthetic lethal drug (the PARP inhibitor ola …
In recent years, a variety of epigenetic regulators have been discovered, and corresponding small molecule inhibitors have been devel …
Beyond Loading: Functions of Plant ARGONAUTE Proteins.
Liang C, Wang X, He H, Xu C, Cui J. Liang C, et al. Int J Mol Sci. 2023 Nov 7;24(22):16054. doi: 10.3390/ijms242216054. Int J Mol Sci. 2023. PMID: 38003244 Free PMC article. Review.
ARGONAUTE (AGO) proteins are key components of the RNA-induced silencing complex (RISC) that mediates gene silencing in eukaryotes. Small-RNA (sRNA) cargoes are selectively loaded into different members of the AGO protein family and then target complementary …
ARGONAUTE (AGO) proteins are key components of the RNA-induced silencing complex (RISC) that mediates gene silencing in eukaryotes. …
1,344 results