Loss of PRSS56 function leads to ocular angle defects and increased susceptibility to high intraocular pressure.
Labelle-Dumais C, Pyatla G, Paylakhi S, Tolman NG, Hameed S, Seymens Y, Dang E, Mandal AK, Senthil S, Khanna RC, Kabra M, Kaur I, John SWM, Chakrabarti S, Nair KS.
Labelle-Dumais C, et al.
Dis Model Mech. 2020 May 29;13(5):dmm042853. doi: 10.1242/dmm.042853.
Dis Model Mech. 2020.
PMID: 32152063
Free PMC article.
Here, we show that Prss56(-/-) mice also exhibit an abnormal iridocorneal angle configuration characterized by a posterior shift of ocular drainage structures relative to the ciliary body and iris. Notably, we show that retina-derived PRSS56 is required between postnatal d …
Here, we show that Prss56(-/-) mice also exhibit an abnormal iridocorneal angle configuration characterized by a posterior shift of ocular d …