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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2002 1
2003 2
2004 1
2009 3
2010 1
2011 1
2012 1
2013 2
2014 7
2015 11
2016 8
2017 5
2018 10
2019 7
2020 7
2021 8
2022 10
2023 7
2024 6

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86 results

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Page 1
Multiple myeloma.
Röllig C, Knop S, Bornhäuser M. Röllig C, et al. Lancet. 2015 May 30;385(9983):2197-208. doi: 10.1016/S0140-6736(14)60493-1. Epub 2014 Dec 23. Lancet. 2015. PMID: 25540889 Review.
Increased understanding of the microenvironmental interactions between malignant plasma cells and the bone marrow niche, and their role in disease progression and acquisition of therapy resistance, has helped the development of novel therapeutic drugs for use in combinatio …
Increased understanding of the microenvironmental interactions between malignant plasma cells and the bone marrow niche, and their ro …
After another decade: LC-MS/MS became routine in clinical diagnostics.
Seger C, Salzmann L. Seger C, et al. Clin Biochem. 2020 Aug;82:2-11. doi: 10.1016/j.clinbiochem.2020.03.004. Epub 2020 Mar 15. Clin Biochem. 2020. PMID: 32188572 Free article. Review.
Tandem mass spectrometry - especially in combination with liquid chromatography (LC-MS/MS) - is applied in a multitude of important diagnostic niches of laboratory medicine. It is unquestioned in its routine use and is often unreplaceable by alternative technologies. ...
Tandem mass spectrometry - especially in combination with liquid chromatography (LC-MS/MS) - is applied in a multitude of important diagnost …
Subcellular proteomics.
Christopher JA, Stadler C, Martin CE, Morgenstern M, Pan Y, Betsinger CN, Rattray DG, Mahdessian D, Gingras AC, Warscheid B, Lehtiö J, Cristea IM, Foster LJ, Emili A, Lilley KS. Christopher JA, et al. Nat Rev Methods Primers. 2021;1:32. doi: 10.1038/s43586-021-00029-y. Epub 2021 Apr 29. Nat Rev Methods Primers. 2021. PMID: 34549195 Free PMC article.
The eukaryotic cell is compartmentalized into subcellular niches, including membrane-bound and membrane-less organelles. Proteins localize to these niches to fulfil their function, enabling discreet biological processes to occur in synchrony. Dynamic movement of pro …
The eukaryotic cell is compartmentalized into subcellular niches, including membrane-bound and membrane-less organelles. Proteins loc …
WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma.
Mitchell K, Sprowls SA, Arora S, Shakya S, Silver DJ, Goins CM, Wallace L, Roversi G, Schafer RE, Kay K, Miller TE, Lauko A, Bassett J, Kashyap A, D'Amato Kass J, Mulkearns-Hubert EE, Johnson S, Alvarado J, Rich JN, Holland EC, Paddison PJ, Patel AP, Stauffer SR, Hubert CG, Lathia JD. Mitchell K, et al. Genes Dev. 2023 Feb 1;37(3-4):86-102. doi: 10.1101/gad.349803.122. Epub 2023 Feb 2. Genes Dev. 2023. PMID: 36732025 Free PMC article.
We developed a spatially resolved loss-of-function screen in GBM patient-derived organoids to identify essential epigenetic regulators in the SOX2-enriched, therapy-resistant niche and identified WDR5 as indispensable for this population. WDR5 is a component of the WRAD co …
We developed a spatially resolved loss-of-function screen in GBM patient-derived organoids to identify essential epigenetic regulators in th …
Acute myeloid leukemia in the vascular niche.
Cogle CR, Bosse RC, Brewer T, Migdady Y, Shirzad R, Kampen KR, Saki N. Cogle CR, et al. Cancer Lett. 2016 Oct 1;380(2):552-560. doi: 10.1016/j.canlet.2015.05.007. Epub 2015 May 8. Cancer Lett. 2016. PMID: 25963886 Review.
Emerging data show that cell-extrinsic factors in the bone marrow microenvironment protect and support AML cells. The vascular niche, in particular, regulates AML cell survival and cell cycling by both paracrine secretion and adhesive contact with endothelial cells. ...
Emerging data show that cell-extrinsic factors in the bone marrow microenvironment protect and support AML cells. The vascular niche, …
Generation of complex bone marrow organoids from human induced pluripotent stem cells.
Frenz-Wiessner S, Fairley SD, Buser M, Goek I, Salewskij K, Jonsson G, Illig D, Zu Putlitz B, Petersheim D, Li Y, Chen PH, Kalauz M, Conca R, Sterr M, Geuder J, Mizoguchi Y, Megens RTA, Linder MI, Kotlarz D, Rudelius M, Penninger JM, Marr C, Klein C. Frenz-Wiessner S, et al. Nat Methods. 2024 May;21(5):868-881. doi: 10.1038/s41592-024-02172-2. Epub 2024 Feb 19. Nat Methods. 2024. PMID: 38374263 Free PMC article.
The human bone marrow (BM) niche sustains hematopoiesis throughout life. We present a method for generating complex BM-like organoids (BMOs) from human induced pluripotent stem cells (iPSCs). ...
The human bone marrow (BM) niche sustains hematopoiesis throughout life. We present a method for generating complex BM-like organoids …
Scientists' warning of threats to mountains.
Schmeller DS, Urbach D, Bates K, Catalan J, Cogălniceanu D, Fisher MC, Friesen J, Füreder L, Gaube V, Haver M, Jacobsen D, Le Roux G, Lin YP, Loyau A, Machate O, Mayer A, Palomo I, Plutzar C, Sentenac H, Sommaruga R, Tiberti R, Ripple WJ. Schmeller DS, et al. Sci Total Environ. 2022 Dec 20;853:158611. doi: 10.1016/j.scitotenv.2022.158611. Epub 2022 Sep 7. Sci Total Environ. 2022. PMID: 36087665 Review.
They are characterized by a rugged, heterogenous landscape with rapidly changing environmental conditions providing myriad ecological niches over relatively small spatial scales. Although montane species are well adapted to life at extremes, they are highly vulnerable to h …
They are characterized by a rugged, heterogenous landscape with rapidly changing environmental conditions providing myriad ecological nic …
Plasticity of the Muscle Stem Cell Microenvironment.
Dinulovic I, Furrer R, Handschin C. Dinulovic I, et al. Adv Exp Med Biol. 2017;1041:141-169. doi: 10.1007/978-3-319-69194-7_8. Adv Exp Med Biol. 2017. PMID: 29204832 Free PMC article. Review.
Their functionality is tightly controlled by a microenvironment composed of a wide variety of factors, such as numerous secreted molecules and different cell types, including blood vessels, oxygen, hormones, motor neurons, immune cells, cytokines, fibroblasts, growth factors, myo …
Their functionality is tightly controlled by a microenvironment composed of a wide variety of factors, such as numerous secreted molecules a …
Learning disability.
Gillberg C, Soderstrom H. Gillberg C, et al. Lancet. 2003 Sep 6;362(9386):811-21. doi: 10.1016/S0140-6736(03)14275-4. Lancet. 2003. PMID: 13678878 Review.
Many countries have abolished a learning disability specialty for medical professionals, but there is a great need to revive this niche of medical knowledge. We know little about quality of life and effects on families of people with learning disability, and research is ne …
Many countries have abolished a learning disability specialty for medical professionals, but there is a great need to revive this niche …
86 results