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N-aryl-3,3,3-trifluoro-2-hydroxy-2-methylpropanamides: KATP potassium channel openers. Modifications on the western region.
Ohnmacht CJ, Russell K, Empfield JR, Frank CA, Gibson KH, Mayhugh DR, McLaren FM, Shapiro HS, Brown FJ, Trainor DA, Ceccarelli C, Lin MM, Masek BB, Forst JM, Harris RJ, Hulsizer JM, Lewis JJ, Silverman SM, Smith RW, Warwick PJ, Kau ST, Chun AL, Grant TL, Howe BB, Neilson KL, et al. Ohnmacht CJ, et al. Among authors: lin mm. J Med Chem. 1996 Nov 8;39(23):4592-601. doi: 10.1021/jm960365n. J Med Chem. 1996. PMID: 8917648
Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression.
Zhou B, Hu J, Xu F, Chen Z, Bai L, Fernandez-Salas E, Lin M, Liu L, Yang CY, Zhao Y, McEachern D, Przybranowski S, Wen B, Sun D, Wang S. Zhou B, et al. J Med Chem. 2018 Jan 25;61(2):462-481. doi: 10.1021/acs.jmedchem.6b01816. Epub 2017 Mar 24. J Med Chem. 2018. PMID: 28339196 Free PMC article.
Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression.
Qin C, Hu Y, Zhou B, Fernandez-Salas E, Yang CY, Liu L, McEachern D, Przybranowski S, Wang M, Stuckey J, Meagher J, Bai L, Chen Z, Lin M, Yang J, Ziazadeh DN, Xu F, Hu J, Xiang W, Huang L, Li S, Wen B, Sun D, Wang S. Qin C, et al. J Med Chem. 2018 Aug 9;61(15):6685-6704. doi: 10.1021/acs.jmedchem.8b00506. Epub 2018 Jul 18. J Med Chem. 2018. PMID: 30019901 Free PMC article.
Hairpin trimer transition state of amyloid fibril.
Sari L, Bali S, Joachimiak LA, Lin MM. Sari L, et al. Among authors: lin mm. Nat Commun. 2024 Mar 29;15(1):2756. doi: 10.1038/s41467-024-46446-x. Nat Commun. 2024. PMID: 38553453 Free PMC article.
Ocular Hypertension and Glaucoma After Open Globe Injury.
Zhang Y, Lin MM. Zhang Y, et al. Among authors: lin mm. Int Ophthalmol Clin. 2024 Apr 1;64(2):63-73. doi: 10.1097/IIO.0000000000000493. Epub 2024 Mar 25. Int Ophthalmol Clin. 2024. PMID: 38525982 No abstract available.
Automated discovery of algorithms from data.
Blazek PJ, Venkatesh K, Lin MM. Blazek PJ, et al. Among authors: lin mm. Nat Comput Sci. 2024 Feb;4(2):110-118. doi: 10.1038/s43588-024-00593-9. Epub 2024 Feb 19. Nat Comput Sci. 2024. PMID: 38374361
121 results