Roberts VA - Search Results

1

Humanization and molecular modeling of the anti-CD4 monoclonal antibody, OKT4A.

Pulito VL, Roberts VA, Adair JR, Rothermel AL, Collins AM, Varga SS, Martocello C, Bodmer M, Jolliffe LK, Zivin RA. Pulito VL, et al. Among authors: roberts va. J Immunol. 1996 Apr 15;156(8):2840-50. J Immunol. 1996. PMID: 8609403

2

Tolerance of single, but not multiple, amino acid replacements in antibody VH CDR 2: a means of minimizing B cell wastage from somatic hypermutation?

Brown M, Rittenburg MB, Chen C, Roberts VA. Brown M, et al. Among authors: roberts va. J Immunol. 1996 May 1;156(9):3285-91. J Immunol. 1996. PMID: 8617951

3

Enhancement and destruction of antibody function by somatic mutation: unequal occurrence is controlled by V gene combinatorial associations.

Chen C, Roberts VA, Stevens S, Brown M, Stenzel-Poore MP, Rittenberg MB. Chen C, et al. Among authors: roberts va. EMBO J. 1995 Jun 15;14(12):2784-94. doi: 10.1002/j.1460-2075.1995.tb07278.x. EMBO J. 1995. PMID: 7796805 Free PMC article.

4

Generation and analysis of random point mutations in an antibody CDR2 sequence: many mutated antibodies lose their ability to bind antigen.

Chen C, Roberts VA, Rittenberg MB. Chen C, et al. Among authors: roberts va. J Exp Med. 1992 Sep 1;176(3):855-66. doi: 10.1084/jem.176.3.855. J Exp Med. 1992. PMID: 1512548 Free PMC article.

5

Harmful somatic mutations: lessons from the dark side.

Wiens GD, Roberts VA, Whitcomb EA, O'Hare T, Stenzel-Poore MP, Rittenberg MB. Wiens GD, et al. Among authors: roberts va. Immunol Rev. 1998 Apr;162:197-209. doi: 10.1111/j.1600-065x.1998.tb01442.x. Immunol Rev. 1998. PMID: 9602365 Review.

6

Antibody remodeling: a general solution to the design of a metal-coordination site in an antibody binding pocket.

Roberts VA, Iverson BL, Iverson SA, Benkovic SJ, Lerner RA, Getzoff ED, Tainer JA. Roberts VA, et al. Proc Natl Acad Sci U S A. 1990 Sep;87(17):6654-8. doi: 10.1073/pnas.87.17.6654. Proc Natl Acad Sci U S A. 1990. PMID: 2395868 Free PMC article.

7

Catalytic antibody model and mutagenesis implicate arginine in transition-state stabilization.

Roberts VA, Stewart J, Benkovic SJ, Getzoff ED. Roberts VA, et al. J Mol Biol. 1994 Jan 21;235(3):1098-116. doi: 10.1006/jmbi.1994.1060. J Mol Biol. 1994. PMID: 8289310

8

Defining antibody-antigen recognition: towards engineered antibodies and epitopes.

Tainer JA, Deal CD, Geysen HM, Roberts VA, Getzoff ED. Tainer JA, et al. Among authors: roberts va. Int Rev Immunol. 1991;7(2):165-88. doi: 10.3109/08830189109061773. Int Rev Immunol. 1991. PMID: 1721650 Review. No abstract available.

9

Unraveling the effect of changes in conformation and compactness at the antibody V(L)-V(H) interface upon antigen binding.

Pellequer JL, Chen Sw, Roberts VA, Tainer JA, Getzoff ED. Pellequer JL, et al. Among authors: roberts va. J Mol Recognit. 1999 Jul-Aug;12(4):267-75. doi: 10.1002/(SICI)1099-1352(199907/08)12:4<267::AID-JMR465>3.0.CO;2-9. J Mol Recognit. 1999. PMID: 10440998

10

Structural basis for amide hydrolysis catalyzed by the 43C9 antibody.

Thayer MM, Olender EH, Arvai AS, Koike CK, Canestrelli IL, Stewart JD, Benkovic SJ, Getzoff ED, Roberts VA. Thayer MM, et al. Among authors: roberts va. J Mol Biol. 1999 Aug 13;291(2):329-45. doi: 10.1006/jmbi.1999.2960. J Mol Biol. 1999. PMID: 10438624

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