Drastic reduction in antimicrobial activity by replacement of Orn residues with Lys in cyclized amphiphilic beta-structural model peptides.
Ando S, Nishihama M, Nishikawa H, Takiguchi H, Lee S, Sugihara G.
Ando S, et al. Among authors: nishikawa h.
Int J Pept Protein Res. 1995 Aug;46(2):97-105. doi: 10.1111/j.1399-3011.1995.tb01324.x.
Int J Pept Protein Res. 1995.
PMID: 8567175
Recent investigation have indicated that cyclic dodeca- and tetradecapeptides, cyclo(-Leu-Orn-Leu-Orn-D-Phe-Pro)2 (Orn-DLL-12) and cyclo(-Leu-Orn-Leu-Orn-Leu-D-Phe-Pro)2 (Orn-DLL-14), which are designed on the basis of a cyclic beta-structural antibiotic, gramicidin S (GS), inhib …
Recent investigation have indicated that cyclic dodeca- and tetradecapeptides, cyclo(-Leu-Orn-Leu-Orn-D-Phe-Pro)2 (Orn-DLL-12) and cyclo(-Le …