Schäffer L - Search Results

1

Interactions of a hybrid insulin/insulin-like growth factor-I analog with chimeric insulin/type I insulin-like growth factor receptors.

Schäffer L, Kjeldsen T, Andersen AS, Wiberg FC, Larsen UD, Cara JF, Mirmira RG, Nakagawa SH, Tager HS. Schäffer L, et al. J Biol Chem. 1993 Feb 15;268(5):3044-7. J Biol Chem. 1993. PMID: 8428981 Free article.

2

Hybrid receptors formed by insulin receptor (IR) and insulin-like growth factor I receptor (IGF-IR) have low insulin and high IGF-1 affinity irrespective of the IR splice variant.

Slaaby R, Schäffer L, Lautrup-Larsen I, Andersen AS, Shaw AC, Mathiasen IS, Brandt J. Slaaby R, et al. Among authors: schaffer l. J Biol Chem. 2006 Sep 8;281(36):25869-74. doi: 10.1074/jbc.M605189200. Epub 2006 Jul 10. J Biol Chem. 2006. PMID: 16831875 Free article.

3

Characterization of the three 125I-iodination isomers of human insulin-like growth factor I (IGF1).

Schäffer L, Larsen UD, Linde S, Hejnaes KR, Skriver L. Schäffer L, et al. Biochim Biophys Acta. 1993 Dec 8;1203(2):205-9. doi: 10.1016/0167-4838(93)90084-5. Biochim Biophys Acta. 1993. PMID: 8268201

4

Alanine scanning mutagenesis of insulin.

Kristensen C, Kjeldsen T, Wiberg FC, Schäffer L, Hach M, Havelund S, Bass J, Steiner DF, Andersen AS. Kristensen C, et al. Among authors: schaffer l. J Biol Chem. 1997 May 16;272(20):12978-83. doi: 10.1074/jbc.272.20.12978. J Biol Chem. 1997. PMID: 9148904 Free article.

5

Expression and characterization of a 70-kDa fragment of the insulin receptor that binds insulin. Minimizing ligand binding domain of the insulin receptor.

Kristensen C, Wiberg FC, Schäffer L, Andersen AS. Kristensen C, et al. Among authors: schaffer l. J Biol Chem. 1998 Jul 10;273(28):17780-6. doi: 10.1074/jbc.273.28.17780. J Biol Chem. 1998. PMID: 9651379 Free article.

6

Identification of determinants that confer ligand specificity on the insulin receptor.

Andersen AS, Kjeldsen T, Wiberg FC, Vissing H, Schäffer L, Rasmussen JS, De Meyts P, Møller NP. Andersen AS, et al. Among authors: schaffer l. J Biol Chem. 1992 Jul 5;267(19):13681-6. J Biol Chem. 1992. PMID: 1320025 Free article.

We have previously shown, using truncated soluble recombinant receptors, that substituting the 62 N-terminal amino acids of the alpha subunit from the insulin-like growth factor I receptor (IGFIR) with the corresponding 68 amino acids from the insulin receptor (IR) results in a c …

We have previously shown, using truncated soluble recombinant receptors, that substituting the 62 N-terminal amino acids of the alpha subuni …

7

Use of mutant insulin receptors in structure-function studies of insulins.

Schäffer L, Markussen J, Kjeldsen T, Andersen AS, Wiberg FC, Tager H. Schäffer L, et al. Biochem Soc Trans. 1992 Nov;20(4):842-3. doi: 10.1042/bst0200842. Biochem Soc Trans. 1992. PMID: 1487077 Review. No abstract available.

8

The ligand specificities of the insulin receptor and the insulin-like growth factor I receptor reside in different regions of a common binding site.

Kjeldsen T, Andersen AS, Wiberg FC, Rasmussen JS, Schäffer L, Balschmidt P, Møller KB, Møller NP. Kjeldsen T, et al. Among authors: schaffer l. Proc Natl Acad Sci U S A. 1991 May 15;88(10):4404-8. doi: 10.1073/pnas.88.10.4404. Proc Natl Acad Sci U S A. 1991. PMID: 1852007 Free PMC article.

9

Immobilized insulin for high capacity affinity chromatography of insulin receptors.

Markussen J, Halstrøm J, Wiberg FC, Schäffer L. Markussen J, et al. Among authors: schaffer l. J Biol Chem. 1991 Oct 5;266(28):18814-8. J Biol Chem. 1991. PMID: 1918001 Free article.

10

A single-chain insulin-like growth factor I/insulin hybrid binds with high affinity to the insulin receptor.

Kristensen C, Andersen AS, Hach M, Wiberg FC, Schäffer L, Kjeldsen T. Kristensen C, et al. Among authors: schaffer l. Biochem J. 1995 Feb 1;305 ( Pt 3)(Pt 3):981-6. doi: 10.1042/bj3050981. Biochem J. 1995. PMID: 7848300 Free PMC article.

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