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Discovery and development of the novel potent orally active thrombin inhibitor N-(9-hydroxy-9-fluorenecarboxy)prolyl trans-4-aminocyclohexylmethyl amide (L-372,460): coapplication of structure-based design and rapid multiple analogue synthesis on solid support.
Brady SF, Stauffer KJ, Lumma WC, Smith GM, Ramjit HG, Lewis SD, Lucas BJ, Gardell SJ, Lyle EA, Appleby SD, Cook JJ, Holahan MA, Stranieri MT, Lynch JJ Jr, Lin JH, Chen IW, Vastag K, Naylor-Olsen AM, Vacca JP. Brady SF, et al. Among authors: smith gm. J Med Chem. 1998 Jan 29;41(3):401-6. doi: 10.1021/jm9705014. J Med Chem. 1998. PMID: 9464370
Design and synthesis of a novel and potent series of inhibitors of cytosolic phospholipase A(2) based on a 1,3-disubstituted propan-2-one skeleton.
Connolly S, Bennion C, Botterell S, Croshaw PJ, Hallam C, Hardy K, Hartopp P, Jackson CG, King SJ, Lawrence L, Mete A, Murray D, Robinson DH, Smith GM, Stein L, Walters I, Wells E, Withnall WJ. Connolly S, et al. Among authors: smith gm. J Med Chem. 2002 Mar 14;45(6):1348-62. doi: 10.1021/jm011050x. J Med Chem. 2002. PMID: 11882004
Early vs Late Anticoagulation in Minor, Moderate, and Major Ischemic Stroke With Atrial Fibrillation: Post Hoc Analysis of the ELAN Randomized Clinical Trial.
Goeldlin MB, Hakim A, Branca M, Abend S, Kneihsl M, Valenzuela Pinilla W, Fenzl S, Rezny-Kasprzak B, Rohner R, Strbian D, Paciaroni M, Thomalla G, Michel P, Nedeltchev K, Gattringer T, Sandset EC, Bonati L, Aguiar de Sousa D, Sylaja PN, Ntaios G, Koga M, Gdovinova Z, Lemmens R, Bornstein NM, Kelly P, Katan M, Horvath T, Dawson J, Fischer U; ELAN Investigators. Goeldlin MB, et al. JAMA Neurol. 2024 May 28:e241450. doi: 10.1001/jamaneurol.2024.1450. Online ahead of print. JAMA Neurol. 2024. PMID: 38805207
Increasing sustainability in palaeoproteomics by optimizing digestion times for large-scale archaeological bone analyses.
Le Meillour L, Sinet-Mathiot V, Ásmundsdóttir RD, Hansen J, Mylopotamitaki D, Troché G, Xia H, Herrera Bethencourt J, Ruebens K, Smith GM, Fagernäs Z, Welker F. Le Meillour L, et al. Among authors: smith gm. iScience. 2024 Mar 11;27(4):109432. doi: 10.1016/j.isci.2024.109432. eCollection 2024 Apr 19. iScience. 2024. PMID: 38550979 Free PMC article.
Stable isotopes show Homo sapiens dispersed into cold steppes ~45,000 years ago at Ilsenhöhle in Ranis, Germany.
Pederzani S, Britton K, Trost M, Fewlass H, Bourgon N, McCormack J, Jaouen K, Dietl H, Döhle HJ, Kirchner A, Lauer T, Le Corre M, McPherron SP, Meller H, Mylopotamitaki D, Orschiedt J, Rougier H, Ruebens K, Schüler T, Sinet-Mathiot V, Smith GM, Talamo S, Tütken T, Welker F, Zavala EI, Weiss M, Hublin JJ. Pederzani S, et al. Among authors: smith gm. Nat Ecol Evol. 2024 Mar;8(3):578-588. doi: 10.1038/s41559-023-02318-z. Epub 2024 Jan 31. Nat Ecol Evol. 2024. PMID: 38297139 Free PMC article. Review.
606 results