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Active immunization with a structurally aggregated PD-L1 antigen breaks T and B immune tolerance in non-human primates and exhibits in vivo anti-tumoral effects in immunocompetent mouse tumor models.
Morera-Díaz Y, Canaán-Haden C, Sánchez-Ramírez J, Bequet-Romero M, Gonzalez-Moya I, Martínez R, Falcón V, Palenzuela D, Ayala-Ávila M, Gavilondo JV. Morera-Díaz Y, et al. Among authors: gavilondo jv. Cancer Lett. 2023 May 1;561:216156. doi: 10.1016/j.canlet.2023.216156. Epub 2023 Apr 3. Cancer Lett. 2023. PMID: 37019172
Characteristics of the specific humoral response in patients with advanced solid tumors after active immunotherapy with a VEGF vaccine, at different antigen doses and using two distinct adjuvants.
Sánchez Ramírez J, Morera Díaz Y, Bequet-Romero M, Hernández-Bernal F, Selman-Housein Bernal KH, de la Torre Santos A, Santiesteban Álvarez ER, Martín Bauta Y, Bermúdez Badell CH, de la Torre Pupo J, Gavilondo JV; CENTAURO-2 Team of Investigators; Ayala Avila M. Sánchez Ramírez J, et al. Among authors: gavilondo jv. BMC Immunol. 2017 Jul 26;18(1):39. doi: 10.1186/s12865-017-0222-z. BMC Immunol. 2017. PMID: 28747172 Free PMC article. Clinical Trial.
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