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BRAF inhibitors reverse the unique molecular signature and phenotype of hairy cell leukemia and exert potent antileukemic activity.
Pettirossi V, Santi A, Imperi E, Russo G, Pucciarini A, Bigerna B, Schiavoni G, Fortini E, Spanhol-Rosseto A, Sportoletti P, Mannucci R, Martelli MP, Klein-Hitpass L, Falini B, Tiacci E. Pettirossi V, et al. Among authors: mannucci r. Blood. 2015 Feb 19;125(8):1207-16. doi: 10.1182/blood-2014-10-603100. Epub 2014 Dec 5. Blood. 2015. PMID: 25480661 Free PMC article. Clinical Trial.
IL-17-producing double-negative T cells are expanded in the peripheral blood, infiltrate the salivary gland and are partially resistant to corticosteroid therapy in patients with Sjögren's syndrome.
Alunno A, Bistoni O, Bartoloni Bocci E, Caterbi S, Bigerna B, Pucciarini A, Tabarrini A, Mannucci R, Beghelli D, Falini B, Gerli R. Alunno A, et al. Among authors: mannucci r. Reumatismo. 2013 Oct 31;65(4):192-8. doi: 10.4081/reumatismo.2013.192. Reumatismo. 2013. PMID: 24192564
BRAF mutations in hairy-cell leukemia.
Tiacci E, Trifonov V, Schiavoni G, Holmes A, Kern W, Martelli MP, Pucciarini A, Bigerna B, Pacini R, Wells VA, Sportoletti P, Pettirossi V, Mannucci R, Elliott O, Liso A, Ambrosetti A, Pulsoni A, Forconi F, Trentin L, Semenzato G, Inghirami G, Capponi M, Di Raimondo F, Patti C, Arcaini L, Musto P, Pileri S, Haferlach C, Schnittger S, Pizzolo G, Foà R, Farinelli L, Haferlach T, Pasqualucci L, Rabadan R, Falini B. Tiacci E, et al. Among authors: mannucci r. N Engl J Med. 2011 Jun 16;364(24):2305-15. doi: 10.1056/NEJMoa1014209. Epub 2011 Jun 11. N Engl J Med. 2011. PMID: 21663470 Free PMC article.
47 results