Pasinelli P - Search Results

1

Glucose hypometabolism prompts RAN translation and exacerbates C9orf72-related ALS/FTD phenotypes.

Nelson AT, Cicardi ME, Markandaiah SS, Han JY, Philp NJ, Welebob E, Haeusler AR, Pasinelli P, Manfredi G, Kawamata H, Trotti D. Nelson AT, et al. Among authors: pasinelli p. EMBO Rep. 2024 May;25(5):2479-2510. doi: 10.1038/s44319-024-00140-7. Epub 2024 Apr 29. EMBO Rep. 2024. PMID: 38684907 Free PMC article.

2

Repeat-associated non-AUG translation in C9orf72-ALS/FTD is driven by neuronal excitation and stress.

Westergard T, McAvoy K, Russell K, Wen X, Pang Y, Morris B, Pasinelli P, Trotti D, Haeusler A. Westergard T, et al. Among authors: pasinelli p. EMBO Mol Med. 2019 Feb;11(2):e9423. doi: 10.15252/emmm.201809423. EMBO Mol Med. 2019. PMID: 30617154 Free PMC article.

3

A mouse model with widespread expression of the C9orf72-linked glycine-arginine dipeptide displays non-lethal ALS/FTD-like phenotypes.

Verdone BM, Cicardi ME, Wen X, Sriramoji S, Russell K, Markandaiah SS, Jensen BK, Krishnamurthy K, Haeusler AR, Pasinelli P, Trotti D. Verdone BM, et al. Among authors: pasinelli p. Sci Rep. 2022 Apr 4;12(1):5644. doi: 10.1038/s41598-022-09593-z. Sci Rep. 2022. PMID: 35379876 Free PMC article.

4

Glucose Hypometabolism Prompts RAN Translation and Exacerbates C9orf72-related ALS/FTD Phenotypes.

Nelson AT, Cicardi ME, Markandaiah SS, Han J, Philp N, Welebob E, Haeusler AR, Pasinelli P, Manfredi G, Kawamata H, Trotti D. Nelson AT, et al. Among authors: pasinelli p. bioRxiv [Preprint]. 2023 Jun 7:2023.06.07.544100. doi: 10.1101/2023.06.07.544100. bioRxiv. 2023. PMID: 37333144 Free PMC article. Updated. Preprint.

5

Antisense proline-arginine RAN dipeptides linked to C9ORF72-ALS/FTD form toxic nuclear aggregates that initiate in vitro and in vivo neuronal death.

Wen X, Tan W, Westergard T, Krishnamurthy K, Markandaiah SS, Shi Y, Lin S, Shneider NA, Monaghan J, Pandey UB, Pasinelli P, Ichida JK, Trotti D. Wen X, et al. Among authors: pasinelli p. Neuron. 2014 Dec 17;84(6):1213-25. doi: 10.1016/j.neuron.2014.12.010. Neuron. 2014. PMID: 25521377 Free PMC article.

6

Pathogenic determinants and mechanisms of ALS/FTD linked to hexanucleotide repeat expansions in the C9orf72 gene.

Wen X, Westergard T, Pasinelli P, Trotti D. Wen X, et al. Among authors: pasinelli p. Neurosci Lett. 2017 Jan 1;636:16-26. doi: 10.1016/j.neulet.2016.09.007. Epub 2016 Sep 13. Neurosci Lett. 2017. PMID: 27619540 Free PMC article. Review.

7

Cell-to-Cell Transmission of Dipeptide Repeat Proteins Linked to C9orf72-ALS/FTD.

Westergard T, Jensen BK, Wen X, Cai J, Kropf E, Iacovitti L, Pasinelli P, Trotti D. Westergard T, et al. Among authors: pasinelli p. Cell Rep. 2016 Oct 11;17(3):645-652. doi: 10.1016/j.celrep.2016.09.032. Cell Rep. 2016. PMID: 27732842 Free PMC article.

8

Excess glutamate secreted from astrocytes drives upregulation of P-glycoprotein in endothelial cells in amyotrophic lateral sclerosis.

Mohamed LA, Markandaiah SS, Bonanno S, Pasinelli P, Trotti D. Mohamed LA, et al. Among authors: pasinelli p. Exp Neurol. 2019 Jun;316:27-38. doi: 10.1016/j.expneurol.2019.04.002. Epub 2019 Apr 9. Exp Neurol. 2019. PMID: 30974102 Free PMC article.

9

Synaptic dysfunction induced by glycine-alanine dipeptides in C9orf72-ALS/FTD is rescued by SV2 replenishment.

Jensen BK, Schuldi MH, McAvoy K, Russell KA, Boehringer A, Curran BM, Krishnamurthy K, Wen X, Westergard T, Ma L, Haeusler AR, Edbauer D, Pasinelli P, Trotti D. Jensen BK, et al. Among authors: pasinelli p. EMBO Mol Med. 2020 May 8;12(5):e10722. doi: 10.15252/emmm.201910722. Epub 2020 Apr 29. EMBO Mol Med. 2020. PMID: 32347002 Free PMC article.

10

C9orf72 poly(PR) mediated neurodegeneration is associated with nucleolar stress.

Cicardi ME, Hallgren JH, Mawrie D, Krishnamurthy K, Markandaiah SS, Nelson AT, Kankate V, Anderson EN, Pasinelli P, Pandey UB, Eischen CM, Trotti D. Cicardi ME, et al. Among authors: pasinelli p. bioRxiv [Preprint]. 2023 Feb 16:2023.02.16.528809. doi: 10.1101/2023.02.16.528809. bioRxiv. 2023. PMID: 36824930 Free PMC article. Updated. Preprint.

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