Haeusler AR - Search Results

1

Glucose hypometabolism prompts RAN translation and exacerbates C9orf72-related ALS/FTD phenotypes.

Nelson AT, Cicardi ME, Markandaiah SS, Han JY, Philp NJ, Welebob E, Haeusler AR, Pasinelli P, Manfredi G, Kawamata H, Trotti D. Nelson AT, et al. Among authors: haeusler ar. EMBO Rep. 2024 May;25(5):2479-2510. doi: 10.1038/s44319-024-00140-7. Epub 2024 Apr 29. EMBO Rep. 2024. PMID: 38684907 Free PMC article.

2

Repeat-associated non-AUG translation in C9orf72-ALS/FTD is driven by neuronal excitation and stress.

Westergard T, McAvoy K, Russell K, Wen X, Pang Y, Morris B, Pasinelli P, Trotti D, Haeusler A. Westergard T, et al. EMBO Mol Med. 2019 Feb;11(2):e9423. doi: 10.15252/emmm.201809423. EMBO Mol Med. 2019. PMID: 30617154 Free PMC article.

3

A mouse model with widespread expression of the C9orf72-linked glycine-arginine dipeptide displays non-lethal ALS/FTD-like phenotypes.

Verdone BM, Cicardi ME, Wen X, Sriramoji S, Russell K, Markandaiah SS, Jensen BK, Krishnamurthy K, Haeusler AR, Pasinelli P, Trotti D. Verdone BM, et al. Among authors: haeusler ar. Sci Rep. 2022 Apr 4;12(1):5644. doi: 10.1038/s41598-022-09593-z. Sci Rep. 2022. PMID: 35379876 Free PMC article.

4

Glucose Hypometabolism Prompts RAN Translation and Exacerbates C9orf72-related ALS/FTD Phenotypes.

Nelson AT, Cicardi ME, Markandaiah SS, Han J, Philp N, Welebob E, Haeusler AR, Pasinelli P, Manfredi G, Kawamata H, Trotti D. Nelson AT, et al. Among authors: haeusler ar. bioRxiv [Preprint]. 2023 Jun 7:2023.06.07.544100. doi: 10.1101/2023.06.07.544100. bioRxiv. 2023. PMID: 37333144 Free PMC article. Updated. Preprint.

5

Synaptic dysfunction induced by glycine-alanine dipeptides in C9orf72-ALS/FTD is rescued by SV2 replenishment.

Jensen BK, Schuldi MH, McAvoy K, Russell KA, Boehringer A, Curran BM, Krishnamurthy K, Wen X, Westergard T, Ma L, Haeusler AR, Edbauer D, Pasinelli P, Trotti D. Jensen BK, et al. Among authors: haeusler ar. EMBO Mol Med. 2020 May 8;12(5):e10722. doi: 10.15252/emmm.201910722. Epub 2020 Apr 29. EMBO Mol Med. 2020. PMID: 32347002 Free PMC article.

6

Breakdown of the central synapses in C9orf72-linked ALS/FTD.

Ghaffari LT, Trotti D, Haeusler AR, Jensen BK. Ghaffari LT, et al. Among authors: haeusler ar. Front Mol Neurosci. 2022 Sep 16;15:1005112. doi: 10.3389/fnmol.2022.1005112. eCollection 2022. Front Mol Neurosci. 2022. PMID: 36187344 Free PMC article. Review.

7

Differential response of C9orf72 transcripts following neuronal depolarization.

Ghaffari LT, Trotti D, Haeusler AR. Ghaffari LT, et al. Among authors: haeusler ar. iScience. 2023 May 24;26(6):106959. doi: 10.1016/j.isci.2023.106959. eCollection 2023 Jun 16. iScience. 2023. PMID: 37332610 Free PMC article.

8

The nuclear import receptor Kapβ2 modifies neurotoxicity mediated by poly(GR) in C9orf72-linked ALS/FTD.

Cicardi ME, Kankate V, Sriramoji S, Krishnamurthy K, Markandaiah SS, Verdone BM, Girdhar A, Nelson A, Rivas LB, Boehringer A, Haeusler AR, Pasinelli P, Guo L, Trotti D. Cicardi ME, et al. Among authors: haeusler ar. Commun Biol. 2024 Mar 28;7(1):376. doi: 10.1038/s42003-024-06071-2. Commun Biol. 2024. PMID: 38548902 Free PMC article.

9

Targeting TNFα produced by astrocytes expressing amyotrophic lateral sclerosis-linked mutant fused in sarcoma prevents neurodegeneration and motor dysfunction in mice.

Jensen BK, McAvoy KJ, Heinsinger NM, Lepore AC, Ilieva H, Haeusler AR, Trotti D, Pasinelli P. Jensen BK, et al. Among authors: haeusler ar. Glia. 2022 Jul;70(7):1426-1449. doi: 10.1002/glia.24183. Epub 2022 Apr 26. Glia. 2022. PMID: 35474517 Free PMC article.

10

The effects of molecular crowding and CpG hypermethylation on DNA G-quadruplexes formed by the C9orf72 nucleotide repeat expansion.

Ozcan KA, Ghaffari LT, Haeusler AR. Ozcan KA, et al. Among authors: haeusler ar. Sci Rep. 2021 Dec 1;11(1):23213. doi: 10.1038/s41598-021-02041-4. Sci Rep. 2021. PMID: 34853325 Free PMC article.

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