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Trk-fused gene plays a critical role in diet-induced adipose tissue expansion and is also involved in thyroid hormone action.
Yamamotoya T, Ohata Y, Akasaka Y, Hasei S, Inoue MK, Nakatsu Y, Kanna M, Yamazaki H, Kushiyama A, Fujishiro M, Ono H, Sakoda H, Yamada T, Ishihara H, Asano T. Yamamotoya T, et al. Among authors: ishihara h. PNAS Nexus. 2024 Apr 9;3(4):pgae150. doi: 10.1093/pnasnexus/pgae150. eCollection 2024 Apr. PNAS Nexus. 2024. PMID: 38681675 Free PMC article.
The prolyl isomerase Pin1 increases β-cell proliferation and enhances insulin secretion.
Nakatsu Y, Mori K, Matsunaga Y, Yamamotoya T, Ueda K, Inoue Y, Mitsuzaki-Miyoshi K, Sakoda H, Fujishiro M, Yamaguchi S, Kushiyama A, Ono H, Ishihara H, Asano T. Nakatsu Y, et al. Among authors: ishihara h. J Biol Chem. 2017 Jul 14;292(28):11886-11895. doi: 10.1074/jbc.M117.780726. Epub 2017 May 31. J Biol Chem. 2017. PMID: 28566287 Free PMC article.
Prolyl Isomerase Pin1 Suppresses Thermogenic Programs in Adipocytes by Promoting Degradation of Transcriptional Co-activator PRDM16.
Nakatsu Y, Matsunaga Y, Yamamotoya T, Ueda K, Inoue MK, Mizuno Y, Nakanishi M, Sano T, Yamawaki Y, Kushiyama A, Sakoda H, Fujishiro M, Ryo A, Ono H, Minamino T, Takahashi SI, Ohno H, Yoneda M, Takahashi K, Ishihara H, Katagiri H, Nishimura F, Kanematsu T, Yamada T, Asano T. Nakatsu Y, et al. Among authors: ishihara h. Cell Rep. 2019 Mar 19;26(12):3221-3230.e3. doi: 10.1016/j.celrep.2019.02.066. Cell Rep. 2019. PMID: 30893596 Free article.
DPP-IV inhibitor anagliptin exerts anti-inflammatory effects on macrophages, adipocytes, and mouse livers by suppressing NF-κB activation.
Shinjo T, Nakatsu Y, Iwashita M, Sano T, Sakoda H, Ishihara H, Kushiyama A, Fujishiro M, Fukushima T, Tsuchiya Y, Kamata H, Nishimura F, Asano T. Shinjo T, et al. Among authors: ishihara h. Am J Physiol Endocrinol Metab. 2015 Aug 1;309(3):E214-23. doi: 10.1152/ajpendo.00553.2014. Epub 2015 May 26. Am J Physiol Endocrinol Metab. 2015. PMID: 26015438 Free article.
Controversy regarding gastric cancer and diabetes.
Fujishiro M, Ishihara H. Fujishiro M, et al. Among authors: ishihara h. J Gastroenterol. 2016 Jan;51(1):80-1. doi: 10.1007/s00535-015-1113-9. Epub 2015 Aug 29. J Gastroenterol. 2016. PMID: 26318727 No abstract available.
1,501 results