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Early, precise, and safe clinical evaluation of the pharmacodynamic effects of novel agents in the intact human tumor microenvironment.
Gundle KR, Rajasekaran K, Houlton J, Deutsch GB, Ow TJ, Maki RG, Pang J, Nathan CO, Clayburgh D, Newman JG, Brinkmann E, Wagner MJ, Pollack SM, Thompson MJ, Li RJ, Mehta V, Schiff BA, Wenig BI, Swiecicki PL, Tang AL, Davis JL, van Zante A, Bertout JA, Jenkins W, Turner A, Grenley M, Burns C, Frazier JP, Merrell A, Sottero KHW, Derry JMJ, Gillespie KC, Mills B, Klinghoffer RA. Gundle KR, et al. Among authors: swiecicki pl. Front Pharmacol. 2024 Apr 12;15:1367581. doi: 10.3389/fphar.2024.1367581. eCollection 2024. Front Pharmacol. 2024. PMID: 38681192 Free PMC article.
Trackable Intratumor Microdosing and Spatial Profiling Provide Early Insights into Activity of Investigational Agents in the Intact Tumor Microenvironment.
Derry JMJ, Burns C, Frazier JP, Beirne E, Grenley M, DuFort CC, Killingbeck E, Leon M, Williams C, Gregory M, Houlton J, Clayburgh D, Swiecicki P, Huszar D, Berger A, Klinghoffer RA. Derry JMJ, et al. Clin Cancer Res. 2023 Sep 15;29(18):3813-3825. doi: 10.1158/1078-0432.CCR-23-0827. Clin Cancer Res. 2023. PMID: 37389981 Free PMC article. Clinical Trial.
Trans-Renal Cell-Free Tumor DNA for Urine-Based Liquid Biopsy of Cancer.
Dermody SM, Bhambhani C, Swiecicki PL, Brenner JC, Tewari M. Dermody SM, et al. Among authors: swiecicki pl. Front Genet. 2022 Apr 27;13:879108. doi: 10.3389/fgene.2022.879108. eCollection 2022. Front Genet. 2022. PMID: 35571046 Free PMC article. Review.
Novel Immunotherapeutic Approaches in Head and Neck Cancer.
Heft Neal ME, Haring CT, Mann JE, Brenner JC, Spector ME, Swiecicki PL. Heft Neal ME, et al. Among authors: swiecicki pl. J Cancer Metastasis Treat. 2019;5:76. doi: 10.20517/2394-4722.2019.32. Epub 2019 Nov 22. J Cancer Metastasis Treat. 2019. PMID: 32661502 Free PMC article.
Tumor immune microenvironment alterations using induction cetuximab in a phase II trial of deintensified therapy for p16-positive oropharynx cancer.
Smith JD, Ludwig ML, Bhangale AD, Brummel C, Swiecicki PL, Worden FP, Chinn SB, Stucken CL, Rosko AJ, Prince MEP, Malloy KM, Casper KA, Bradford CR, Chepeha DB, Shah J, Schonewolf CA, McHugh JB, Nyati MK, Eisbruch A, Mierzwa ML, Spector ME, Brenner JC. Smith JD, et al. Among authors: swiecicki pl. Head Neck. 2023 May;45(5):1281-1287. doi: 10.1002/hed.27344. Epub 2023 Mar 18. Head Neck. 2023. PMID: 36932871 Clinical Trial.
Human papilloma virus circulating tumor DNA assay predicts treatment response in recurrent/metastatic head and neck squamous cell carcinoma.
Haring CT, Bhambhani C, Brummel C, Jewell B, Bellile E, Heft Neal ME, Sandford E, Spengler RM, Bhangale A, Spector ME, McHugh J, Prince ME, Mierzwa M, Worden FP, Tewari M, Swiecicki PL, Brenner JC. Haring CT, et al. Among authors: swiecicki pl. Oncotarget. 2021 Jun 22;12(13):1214-1229. doi: 10.18632/oncotarget.27992. eCollection 2021 Jun 22. Oncotarget. 2021. PMID: 34194620 Free PMC article.
Window of opportunity trials in head and neck cancer.
Farlow JL, Birkeland AC, Swiecicki PL, Brenner JC, Spector ME. Farlow JL, et al. Among authors: swiecicki pl. J Cancer Metastasis Treat. 2019;5:18. doi: 10.20517/2394-4722.2018.100. Epub 2019 Mar 18. J Cancer Metastasis Treat. 2019. PMID: 31321307 Free PMC article.
74 results