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Early, precise, and safe clinical evaluation of the pharmacodynamic effects of novel agents in the intact human tumor microenvironment.
Gundle KR, Rajasekaran K, Houlton J, Deutsch GB, Ow TJ, Maki RG, Pang J, Nathan CO, Clayburgh D, Newman JG, Brinkmann E, Wagner MJ, Pollack SM, Thompson MJ, Li RJ, Mehta V, Schiff BA, Wenig BI, Swiecicki PL, Tang AL, Davis JL, van Zante A, Bertout JA, Jenkins W, Turner A, Grenley M, Burns C, Frazier JP, Merrell A, Sottero KHW, Derry JMJ, Gillespie KC, Mills B, Klinghoffer RA. Gundle KR, et al. Among authors: houlton j. Front Pharmacol. 2024 Apr 12;15:1367581. doi: 10.3389/fphar.2024.1367581. eCollection 2024. Front Pharmacol. 2024. PMID: 38681192 Free PMC article.
Trackable Intratumor Microdosing and Spatial Profiling Provide Early Insights into Activity of Investigational Agents in the Intact Tumor Microenvironment.
Derry JMJ, Burns C, Frazier JP, Beirne E, Grenley M, DuFort CC, Killingbeck E, Leon M, Williams C, Gregory M, Houlton J, Clayburgh D, Swiecicki P, Huszar D, Berger A, Klinghoffer RA. Derry JMJ, et al. Among authors: houlton j. Clin Cancer Res. 2023 Sep 15;29(18):3813-3825. doi: 10.1158/1078-0432.CCR-23-0827. Clin Cancer Res. 2023. PMID: 37389981 Free PMC article. Clinical Trial.
Peripheral lymphocytes and lactate dehydrogenase correlate with response and survival in head and neck cancers treated with immune checkpoint inhibitors.
Pan C, Wu QV, Voutsinas J, Houlton JJ, Barber B, Rizvi ZH, Marchiano E, Futran N, Laramore GE, Liao JJ, Parvathaneni U, Martins RG, Fromm JR, Rodriguez CP. Pan C, et al. Among authors: houlton jj. Cancer Med. 2023 Apr;12(8):9384-9391. doi: 10.1002/cam4.5697. Epub 2023 Feb 21. Cancer Med. 2023. PMID: 36806947 Free PMC article.
Neutrophil to lymphocyte ratio and peripheral blood biomarkers correlate with survival outcomes but not response among head and neck and salivary cancer treated with pembrolizumab and vorinostat.
Pan C, Wu QV, Voutsinas J, Houlton JJ, Barber B, Futran N, Laramore GE, Liao JJ, Parvathaneni U, Martins RG, Fromm JR, Rodriguez CP. Pan C, et al. Among authors: houlton jj. Head Neck. 2023 Feb;45(2):391-397. doi: 10.1002/hed.27252. Epub 2022 Nov 22. Head Neck. 2023. PMID: 36412064 Free PMC article. Clinical Trial.
Effect of the intratumoral microbiota on spatial and cellular heterogeneity in cancer.
Galeano Niño JL, Wu H, LaCourse KD, Kempchinsky AG, Baryiames A, Barber B, Futran N, Houlton J, Sather C, Sicinska E, Taylor A, Minot SS, Johnston CD, Bullman S. Galeano Niño JL, et al. Among authors: houlton j. Nature. 2022 Nov;611(7937):810-817. doi: 10.1038/s41586-022-05435-0. Epub 2022 Nov 16. Nature. 2022. PMID: 36385528 Free PMC article.
94 results