Hart T - Search Results

1

Efficient gene knockout and genetic interaction screening using the in4mer CRISPR/Cas12a multiplex knockout platform.

Esmaeili Anvar N, Lin C, Ma X, Wilson LL, Steger R, Sangree AK, Colic M, Wang SH, Doench JG, Hart T. Esmaeili Anvar N, et al. Among authors: hart t. Nat Commun. 2024 Apr 27;15(1):3577. doi: 10.1038/s41467-024-47795-3. Nat Commun. 2024. PMID: 38678031 Free PMC article.

2

Discovery of putative tumor suppressors from CRISPR screens reveals rewired lipid metabolism in acute myeloid leukemia cells.

Lenoir WF, Morgado M, DeWeirdt PC, McLaughlin M, Griffith AL, Sangree AK, Feeley MN, Esmaeili Anvar N, Kim E, Bertolet LL, Colic M, Dede M, Doench JG, Hart T. Lenoir WF, et al. Among authors: hart t. Nat Commun. 2021 Nov 11;12(1):6506. doi: 10.1038/s41467-021-26867-8. Nat Commun. 2021. PMID: 34764293 Free PMC article.

3

Common computational tools for analyzing CRISPR screens.

Colic M, Hart T. Colic M, et al. Among authors: hart t. Emerg Top Life Sci. 2021 Dec 21;5(6):779-788. doi: 10.1042/ETLS20210222. Emerg Top Life Sci. 2021. PMID: 34881774 Free PMC article. Review.

4

Efficient gene knockout and genetic interactions: the IN4MER CRISPR/Cas12a multiplex knockout platform.

Anvar NE, Lin C, Ma X, Wilson LL, Steger R, Sangree AK, Colic M, Wang SH, Doench JG, Hart T. Anvar NE, et al. Among authors: hart t. bioRxiv [Preprint]. 2023 Sep 5:2023.01.03.522655. doi: 10.1101/2023.01.03.522655. bioRxiv. 2023. PMID: 36712129 Free PMC article. Updated. Preprint.

5

A network of human functional gene interactions from knockout fitness screens in cancer cells.

Kim E, Dede M, Lenoir WF, Wang G, Srinivasan S, Colic M, Hart T. Kim E, et al. Among authors: hart t. Life Sci Alliance. 2019 Apr 12;2(2):e201800278. doi: 10.26508/lsa.201800278. Print 2019 Apr. Life Sci Alliance. 2019. PMID: 30979825 Free PMC article.

6

Chemogenetic interactions in human cancer cells.

Colic M, Hart T. Colic M, et al. Among authors: hart t. Comput Struct Biotechnol J. 2019 Oct 26;17:1318-1325. doi: 10.1016/j.csbj.2019.09.006. eCollection 2019. Comput Struct Biotechnol J. 2019. PMID: 31921397 Free PMC article. Review.

7

CRISPR/CAS9-based DNA damage response screens reveal gene-drug interactions.

Su D, Feng X, Colic M, Wang Y, Zhang C, Wang C, Tang M, Hart T, Chen J. Su D, et al. Among authors: hart t. DNA Repair (Amst). 2020 Mar;87:102803. doi: 10.1016/j.dnarep.2020.102803. Epub 2020 Jan 16. DNA Repair (Amst). 2020. PMID: 31991288 Free PMC article.

8

Genome-wide In Vivo CNS Screening Identifies Genes that Modify CNS Neuronal Survival and mHTT Toxicity.

Wertz MH, Mitchem MR, Pineda SS, Hachigian LJ, Lee H, Lau V, Powers A, Kulicke R, Madan GK, Colic M, Therrien M, Vernon A, Beja-Glasser VF, Hegde M, Gao F, Kellis M, Hart T, Doench JG, Heiman M. Wertz MH, et al. Among authors: hart t. Neuron. 2020 Apr 8;106(1):76-89.e8. doi: 10.1016/j.neuron.2020.01.004. Epub 2020 Jan 30. Neuron. 2020. PMID: 32004439 Free PMC article.

9

PICKLES v3: the updated database of pooled in vitro CRISPR knockout library essentiality screens.

Novak LC, Chou J, Colic M, Bristow CA, Hart T. Novak LC, et al. Among authors: hart t. Nucleic Acids Res. 2023 Jan 6;51(D1):D1117-D1121. doi: 10.1093/nar/gkac982. Nucleic Acids Res. 2023. PMID: 36350677 Free PMC article.

10

Pooled library screening with multiplexed Cpf1 library.

Liu J, Srinivasan S, Li CY, Ho IL, Rose J, Shaheen M, Wang G, Yao W, Deem A, Bristow C, Hart T, Draetta G. Liu J, et al. Among authors: hart t. Nat Commun. 2019 Jul 17;10(1):3144. doi: 10.1038/s41467-019-10963-x. Nat Commun. 2019. PMID: 31316073 Free PMC article.

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