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MutS/MutL crystal structure reveals that the MutS sliding clamp loads MutL onto DNA.
Groothuizen FS, Winkler I, Cristóvão M, Fish A, Winterwerp HH, Reumer A, Marx AD, Hermans N, Nicholls RA, Murshudov GN, Lebbink JH, Friedhoff P, Sixma TK. Groothuizen FS, et al. Among authors: sixma tk. Elife. 2015 Jul 11;4:e06744. doi: 10.7554/eLife.06744. Elife. 2015. PMID: 26163658 Free PMC article.
The unstructured linker arms of MutL enable GATC site incision beyond roadblocks during initiation of DNA mismatch repair.
Mardenborough YSN, Nitsenko K, Laffeber C, Duboc C, Sahin E, Quessada-Vial A, Winterwerp HHK, Sixma TK, Kanaar R, Friedhoff P, Strick TR, Lebbink JHG. Mardenborough YSN, et al. Among authors: sixma tk. Nucleic Acids Res. 2019 Dec 16;47(22):11667-11680. doi: 10.1093/nar/gkz834. Nucleic Acids Res. 2019. PMID: 31598722 Free PMC article.
The selection process of licensing a DNA mismatch for repair.
Fernandez-Leiro R, Bhairosing-Kok D, Kunetsky V, Laffeber C, Winterwerp HH, Groothuizen F, Fish A, Lebbink JHG, Friedhoff P, Sixma TK, Lamers MH. Fernandez-Leiro R, et al. Among authors: sixma tk. Nat Struct Mol Biol. 2021 Apr;28(4):373-381. doi: 10.1038/s41594-021-00577-7. Epub 2021 Apr 5. Nat Struct Mol Biol. 2021. PMID: 33820992
Unexpected moves: a conformational change in MutSα enables high-affinity DNA mismatch binding.
Bruekner SR, Pieters W, Fish A, Liaci AM, Scheffers S, Rayner E, Kaldenbach D, Drost L, Dekker M, van Hees-Stuivenberg S, Delzenne-Goette E, de Konink C, Houlleberghs H, Dubbink HJ, AlSaegh A, de Wind N, Förster F, Te Riele H, Sixma TK. Bruekner SR, et al. Among authors: sixma tk. Nucleic Acids Res. 2023 Feb 22;51(3):1173-1188. doi: 10.1093/nar/gkad015. Nucleic Acids Res. 2023. PMID: 36715327 Free PMC article.
128 results