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MutS/MutL crystal structure reveals that the MutS sliding clamp loads MutL onto DNA.
Groothuizen FS, Winkler I, Cristóvão M, Fish A, Winterwerp HH, Reumer A, Marx AD, Hermans N, Nicholls RA, Murshudov GN, Lebbink JH, Friedhoff P, Sixma TK. Groothuizen FS, et al. Among authors: friedhoff p. Elife. 2015 Jul 11;4:e06744. doi: 10.7554/eLife.06744. Elife. 2015. PMID: 26163658 Free PMC article.
The unstructured linker arms of MutL enable GATC site incision beyond roadblocks during initiation of DNA mismatch repair.
Mardenborough YSN, Nitsenko K, Laffeber C, Duboc C, Sahin E, Quessada-Vial A, Winterwerp HHK, Sixma TK, Kanaar R, Friedhoff P, Strick TR, Lebbink JHG. Mardenborough YSN, et al. Among authors: friedhoff p. Nucleic Acids Res. 2019 Dec 16;47(22):11667-11680. doi: 10.1093/nar/gkz834. Nucleic Acids Res. 2019. PMID: 31598722 Free PMC article.
The selection process of licensing a DNA mismatch for repair.
Fernandez-Leiro R, Bhairosing-Kok D, Kunetsky V, Laffeber C, Winterwerp HH, Groothuizen F, Fish A, Lebbink JHG, Friedhoff P, Sixma TK, Lamers MH. Fernandez-Leiro R, et al. Among authors: friedhoff p. Nat Struct Mol Biol. 2021 Apr;28(4):373-381. doi: 10.1038/s41594-021-00577-7. Epub 2021 Apr 5. Nat Struct Mol Biol. 2021. PMID: 33820992
Generation of DNA nanocircles containing mismatched bases.
Xiao Y, Jung C, Marx AD, Winkler I, Wyman C, Lebbink JH, Friedhoff P, Cristovao M. Xiao Y, et al. Among authors: friedhoff p. Biotechniques. 2011 Oct;51(4):259-62, 264-5. doi: 10.2144/000113749. Biotechniques. 2011. PMID: 21988692 Free article.
Dual daughter strand incision is processive and increases the efficiency of DNA mismatch repair.
Hermans N, Laffeber C, Cristovão M, Artola-Borán M, Mardenborough Y, Ikpa P, Jaddoe A, Winterwerp HH, Wyman C, Jiricny J, Kanaar R, Friedhoff P, Lebbink JH. Hermans N, et al. Among authors: friedhoff p. Nucleic Acids Res. 2016 Aug 19;44(14):6770-86. doi: 10.1093/nar/gkw411. Epub 2016 May 12. Nucleic Acids Res. 2016. PMID: 27174933 Free PMC article.
69 results