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Discovery of harmiprims, harmine-primaquine hybrids, as potent and selective anticancer and antimalarial compounds.
Pavić K, Poje G, Pessanha de Carvalho L, Tandarić T, Marinović M, Fontinha D, Held J, Prudêncio M, Piantanida I, Vianello R, Krošl Knežević I, Perković I, Rajić Z. Pavić K, et al. Among authors: perkovic i. Bioorg Med Chem. 2024 May 1;105:117734. doi: 10.1016/j.bmc.2024.117734. Epub 2024 Apr 23. Bioorg Med Chem. 2024. PMID: 38677112
Primaquine hybrids as promising antimycobacterial and antimalarial agents.
Pavić K, Perković I, Pospíšilová Š, Machado M, Fontinha D, Prudêncio M, Jampilek J, Coffey A, Endersen L, Rimac H, Zorc B. Pavić K, et al. Among authors: perkovic i. Eur J Med Chem. 2018 Jan 1;143:769-779. doi: 10.1016/j.ejmech.2017.11.083. Epub 2017 Dec 2. Eur J Med Chem. 2018. PMID: 29220797
Primaquine derivatives: Modifications of the terminal amino group.
Zorc B, Perković I, Pavić K, Rajić Z, Beus M. Zorc B, et al. Among authors: perkovic i. Eur J Med Chem. 2019 Nov 15;182:111640. doi: 10.1016/j.ejmech.2019.111640. Epub 2019 Aug 23. Eur J Med Chem. 2019. PMID: 31472472 Free PMC article. Review.
Harmicines - harmine and cinnamic acid hybrids as novel antiplasmodial hits.
Perković I, Raić-Malić S, Fontinha D, Prudêncio M, Pessanha de Carvalho L, Held J, Tandarić T, Vianello R, Zorc B, Rajić Z. Perković I, et al. Eur J Med Chem. 2020 Feb 1;187:111927. doi: 10.1016/j.ejmech.2019.111927. Epub 2019 Nov 29. Eur J Med Chem. 2020. PMID: 31812035
Further investigation of harmicines as novel antiplasmodial agents: Synthesis, structure-activity relationship and insight into the mechanism of action.
Marinović M, Poje G, Perković I, Fontinha D, Prudêncio M, Held J, Pessanha de Carvalho L, Tandarić T, Vianello R, Rajić Z. Marinović M, et al. Among authors: perkovic i. Eur J Med Chem. 2021 Nov 15;224:113687. doi: 10.1016/j.ejmech.2021.113687. Epub 2021 Jul 5. Eur J Med Chem. 2021. PMID: 34274829
Novel Harmicines with Improved Potency against Plasmodium.
Marinović M, Perković I, Fontinha D, Prudêncio M, Held J, Pessanha de Carvalho L, Tandarić T, Vianello R, Zorc B, Rajić Z. Marinović M, et al. Among authors: perkovic i. Molecules. 2020 Sep 23;25(19):4376. doi: 10.3390/molecules25194376. Molecules. 2020. PMID: 32977642 Free PMC article.
38 results