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Structure-guided design of a selective inhibitor of the methyltransferase KMT9 with cellular activity.
Wang S, Klein SO, Urban S, Staudt M, Barthes NPF, Willmann D, Bacher J, Sum M, Bauer H, Peng L, Rennar GA, Gratzke C, Schüle KM, Zhang L, Einsle O, Greschik H, MacLeod C, Thomson CG, Jung M, Metzger E, Schüle R. Wang S, et al. Among authors: greschik h. Nat Commun. 2024 Jan 2;15(1):43. doi: 10.1038/s41467-023-44243-6. Nat Commun. 2024. PMID: 38167811 Free PMC article.
KMT9 monomethylates histone H4 lysine 12 and controls proliferation of prostate cancer cells.
Metzger E, Wang S, Urban S, Willmann D, Schmidt A, Offermann A, Allen A, Sum M, Obier N, Cottard F, Ulferts S, Preca BT, Hermann B, Maurer J, Greschik H, Hornung V, Einsle O, Perner S, Imhof A, Jung M, Schüle R. Metzger E, et al. Among authors: greschik h. Nat Struct Mol Biol. 2019 May;26(5):361-371. doi: 10.1038/s41594-019-0219-9. Epub 2019 May 6. Nat Struct Mol Biol. 2019. PMID: 31061526
The histone code reader Spin1 controls skeletal muscle development.
Greschik H, Duteil D, Messaddeq N, Willmann D, Arrigoni L, Sum M, Jung M, Metzger D, Manke T, Günther T, Schüle R. Greschik H, et al. Cell Death Dis. 2017 Nov 23;8(11):e3173. doi: 10.1038/cddis.2017.468. Cell Death Dis. 2017. PMID: 29168801 Free PMC article.
The histone code reader SPIN1 controls RET signaling in liposarcoma.
Franz H, Greschik H, Willmann D, Ozretić L, Jilg CA, Wardelmann E, Jung M, Buettner R, Schüle R. Franz H, et al. Among authors: greschik h. Oncotarget. 2015 Mar 10;6(7):4773-89. doi: 10.18632/oncotarget.3000. Oncotarget. 2015. PMID: 25749382 Free PMC article.
LSD1 promotes oxidative metabolism of white adipose tissue.
Duteil D, Metzger E, Willmann D, Karagianni P, Friedrichs N, Greschik H, Günther T, Buettner R, Talianidis I, Metzger D, Schüle R. Duteil D, et al. Among authors: greschik h. Nat Commun. 2014 Jun 10;5:4093. doi: 10.1038/ncomms5093. Nat Commun. 2014. PMID: 24912735 Free PMC article.
Selective targeting of epigenetic reader domains.
Greschik H, Schüle R, Günther T. Greschik H, et al. Expert Opin Drug Discov. 2017 May;12(5):449-463. doi: 10.1080/17460441.2017.1303474. Epub 2017 Mar 14. Expert Opin Drug Discov. 2017. PMID: 28277835 Review.
26 results