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Alkynyl-coumarinyl ethers as MAO-B inhibitors.
Mertens MD, Hinz S, Müller CE, Gütschow M. Mertens MD, et al. Among authors: gutschow m. Bioorg Med Chem. 2014 Mar 15;22(6):1916-28. doi: 10.1016/j.bmc.2014.01.046. Epub 2014 Feb 8. Bioorg Med Chem. 2014. PMID: 24560738
Cell-permeable high-affinity tracers for Gq proteins provide structural insights, reveal distinct binding kinetics and identify small molecule inhibitors.
Kuschak M, Namasivayam V, Rafehi M, Voss JH, Garg J, Schlegel JG, Abdelrahman A, Kehraus S, Reher R, Küppers J, Sylvester K, Hinz S, Matthey M, Wenzel D, Fleischmann BK, Pfeifer A, Inoue A, Gütschow M, König GM, Müller CE. Kuschak M, et al. Among authors: gutschow m. Br J Pharmacol. 2020 Apr;177(8):1898-1916. doi: 10.1111/bph.14960. Epub 2020 Feb 11. Br J Pharmacol. 2020. PMID: 31881095 Free PMC article.
Chromenones as Multineurotargeting Inhibitors of Human Enzymes.
Lemke C, Christmann J, Yin J, Alonso JM, Serrano E, Chioua M, Ismaili L, Martínez-Grau MA, Beadle CD, Vetman T, Dato FM, Bartz U, Elsinghorst PW, Pietsch M, Müller CE, Iriepa I, Wille T, Marco-Contelles J, Gütschow M. Lemke C, et al. Among authors: gutschow m. ACS Omega. 2019 Dec 11;4(26):22161-22168. doi: 10.1021/acsomega.9b03409. eCollection 2019 Dec 24. ACS Omega. 2019. PMID: 31891098 Free PMC article.
Thioesterase-mediated side chain transesterification generates potent Gq signaling inhibitor FR900359.
Hermes C, Richarz R, Wirtz DA, Patt J, Hanke W, Kehraus S, Voß JH, Küppers J, Ohbayashi T, Namasivayam V, Alenfelder J, Inoue A, Mergaert P, Gütschow M, Müller CE, Kostenis E, König GM, Crüsemann M. Hermes C, et al. Among authors: gutschow m. Nat Commun. 2021 Jan 8;12(1):144. doi: 10.1038/s41467-020-20418-3. Nat Commun. 2021. PMID: 33420046 Free PMC article.
Targeting the Main Protease of SARS-CoV-2: From the Establishment of High Throughput Screening to the Design of Tailored Inhibitors.
Breidenbach J, Lemke C, Pillaiyar T, Schäkel L, Al Hamwi G, Diett M, Gedschold R, Geiger N, Lopez V, Mirza S, Namasivayam V, Schiedel AC, Sylvester K, Thimm D, Vielmuth C, Phuong Vu L, Zyulina M, Bodem J, Gütschow M, Müller CE. Breidenbach J, et al. Among authors: gutschow m. Angew Chem Int Ed Engl. 2021 Apr 26;60(18):10423-10429. doi: 10.1002/anie.202016961. Epub 2021 Mar 24. Angew Chem Int Ed Engl. 2021. PMID: 33655614 Free PMC article.
3CL Protease Inhibitors with an Electrophilic Arylketone Moiety as Anti-SARS-CoV-2 Agents.
Konno S, Kobayashi K, Senda M, Funai Y, Seki Y, Tamai I, Schäkel L, Sakata K, Pillaiyar T, Taguchi A, Taniguchi A, Gütschow M, Müller CE, Takeuchi K, Hirohama M, Kawaguchi A, Kojima M, Senda T, Shirasaka Y, Kamitani W, Hayashi Y. Konno S, et al. Among authors: gutschow m. J Med Chem. 2022 Feb 24;65(4):2926-2939. doi: 10.1021/acs.jmedchem.1c00665. Epub 2021 Jul 27. J Med Chem. 2022. PMID: 34313428
New Drug Modalities in Medicinal Chemistry, Pharmacology, and Translational Science: Joint Virtual Special Issue by Journal of Medicinal Chemistry, ACS Medicinal Chemistry Letters, and ACS Pharmacology & Translational Science.
Müller CE, Hansen FK, Gütschow M, Lindsley CW, Liotta D. Müller CE, et al. Among authors: gutschow m. ACS Med Chem Lett. 2021 Sep 30;12(10):1508-1509. doi: 10.1021/acsmedchemlett.1c00476. eCollection 2021 Oct 14. ACS Med Chem Lett. 2021. PMID: 34676023 Free PMC article. No abstract available.
249 results