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Comparative Impact of an Optimized PK/PD Target Attainment of Piperacillin-Tazobactam vs. Meropenem on the Trend over Time of SOFA Score and Inflammatory Biomarkers in Critically Ill Patients Receiving Continuous Infusion Monotherapy for Treating Documented Gram-Negative BSIs and/or VAP.
Gatti M, Rinaldi M, Tonetti T, Siniscalchi A, Viale P, Pea F. Gatti M, et al. Among authors: siniscalchi a. Antibiotics (Basel). 2024 Mar 25;13(4):296. doi: 10.3390/antibiotics13040296. Antibiotics (Basel). 2024. PMID: 38666972 Free PMC article.
Assessment of a PK/PD Target of Continuous Infusion Beta-Lactams Useful for Preventing Microbiological Failure and/or Resistance Development in Critically Ill Patients Affected by Documented Gram-Negative Infections.
Gatti M, Cojutti PG, Pascale R, Tonetti T, Laici C, Dell'Olio A, Siniscalchi A, Giannella M, Viale P, Pea F. Gatti M, et al. Among authors: siniscalchi a. Antibiotics (Basel). 2021 Oct 27;10(11):1311. doi: 10.3390/antibiotics10111311. Antibiotics (Basel). 2021. PMID: 34827249 Free PMC article.
Impact of Maximizing Css/MIC Ratio on Efficacy of Continuous Infusion Meropenem Against Documented Gram-Negative Infections in Critically Ill Patients and Population Pharmacokinetic/Pharmacodynamic Analysis to Support Treatment Optimization.
Cojutti PG, Gatti M, Rinaldi M, Tonetti T, Laici C, Mega C, Siniscalchi A, Giannella M, Viale P, Pea F. Cojutti PG, et al. Among authors: siniscalchi a. Front Pharmacol. 2021 Dec 8;12:781892. doi: 10.3389/fphar.2021.781892. eCollection 2021. Front Pharmacol. 2021. PMID: 34955851 Free PMC article.
A descriptive pharmacokinetic/pharmacodynamic analysis of continuous infusion ceftazidime-avibactam for treating DTR gram-negative infections in a case series of critically ill patients undergoing continuous veno-venous haemodiafiltration (CVVHDF).
Gatti M, Rinaldi M, Gaibani P, Siniscalchi A, Tonetti T, Giannella M, Viale P, Pea F. Gatti M, et al. Among authors: siniscalchi a. J Crit Care. 2023 Aug;76:154301. doi: 10.1016/j.jcrc.2023.154301. Epub 2023 Apr 12. J Crit Care. 2023. PMID: 37059003 Free article.
Real-Time TDM-Based Expert Clinical Pharmacological Advice Program for Attaining Aggressive Pharmacokinetic/Pharmacodynamic Target of Continuous Infusion Meropenem in the Treatment of Critically Ill Patients with Documented Gram-Negative Infections Undergoing Continuous Veno-Venous Hemodiafiltration.
Gatti M, Rinaldi M, Tonetti T, Siniscalchi A, Viale P, Pea F. Gatti M, et al. Among authors: siniscalchi a. Antibiotics (Basel). 2023 Oct 10;12(10):1524. doi: 10.3390/antibiotics12101524. Antibiotics (Basel). 2023. PMID: 37887225 Free PMC article.
Role of a Real-Time TDM-Based Expert Clinical Pharmacological Advice Program in Optimizing the Early Pharmacokinetic/Pharmacodynamic Target Attainment of Continuous Infusion Beta-Lactams among Orthotopic Liver Transplant Recipients with Documented or Suspected Gram-Negative Infections.
Gatti M, Rinaldi M, Laici C, Siniscalchi A, Viale P, Pea F. Gatti M, et al. Among authors: siniscalchi a. Antibiotics (Basel). 2023 Nov 7;12(11):1599. doi: 10.3390/antibiotics12111599. Antibiotics (Basel). 2023. PMID: 37998801 Free PMC article.
Could an Optimized Joint Pharmacokinetic/Pharmacodynamic Target Attainment of Continuous Infusion Piperacillin-Tazobactam Be a Valuable Innovative Approach for Maximizing the Effectiveness of Monotherapy Even in the Treatment of Critically Ill Patients with Documented Extended-Spectrum Beta-Lactamase-Producing Enterobacterales Bloodstream Infections and/or Ventilator-Associated Pneumonia?
Gatti M, Rinaldi M, Tonetti T, Siniscalchi A, Viale P, Pea F. Gatti M, et al. Among authors: siniscalchi a. Antibiotics (Basel). 2023 Dec 14;12(12):1736. doi: 10.3390/antibiotics12121736. Antibiotics (Basel). 2023. PMID: 38136770 Free PMC article.
Expert clinical pharmacological advice may make an antimicrobial TDM program for emerging candidates more clinically useful in tailoring therapy of critically ill patients.
Gatti M, Cojutti PG, Bartoletti M, Tonetti T, Bianchini A, Ramirez S, Pizzilli G, Ambretti S, Giannella M, Mancini R, Siniscalchi A, Viale P, Pea F. Gatti M, et al. Among authors: siniscalchi a. Crit Care. 2022 Jun 14;26(1):178. doi: 10.1186/s13054-022-04050-9. Crit Care. 2022. PMID: 35701812 Free PMC article.
Pharmacokinetics/pharmacodynamics of cefiderocol administered by continuous infusion in a case series of critically ill patients with carbapenem-resistant Acinetobacter baumannii infections undergoing continuous venovenous haemodiafiltration (CVVHDF).
Gatti M, Rinaldi M, Tonetti T, Gaibani P, Siniscalchi A, Viale P, Pea F. Gatti M, et al. Among authors: siniscalchi a. Int J Antimicrob Agents. 2023 Aug;62(2):106852. doi: 10.1016/j.ijantimicag.2023.106852. Epub 2023 May 14. Int J Antimicrob Agents. 2023. PMID: 37192727
352 results