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A concept of dual-responsive prodrugs based on oligomerization-controlled reactivity of ester groups: an improvement of cancer cells versus neutrophils selectivity of camptothecin.
Klemt I, Reshetnikov V, Dutta S, Bila G, Bilyy R, Cuartero IC, Hidalgo A, Wünsche A, Böhm M, Wondrak M, Kunz-Schughart LA, Tietze R, Beierlein F, Imhof P, Gensberger-Reigl S, Pischetsrieder M, Körber M, Jost T, Mokhir A. Klemt I, et al. RSC Med Chem. 2024 Jan 31;15(4):1189-1197. doi: 10.1039/d3md00609c. eCollection 2024 Apr 24. RSC Med Chem. 2024. PMID: 38665843 Free PMC article.
3D-Shaped Binders of Unfolded Proteins Inducing Cancer Cell-Specific Endoplasmic Reticulum Stress In Vitro and In Vivo.
Klemt I, Varzatskii O, Selin R, Vakarov S, Kovalska V, Bila G, Bilyy R, Voloshin Y, Cuartero IC, Hidalgo A, Frey B, Becker I, Friedrich B, Tietze R, Friedrich RP, Alexiou C, Ursu EL, Rotaru A, Solymosi I, Pérez-Ojeda ME, Mokhir A. Klemt I, et al. J Am Chem Soc. 2023 Oct 11;145(40):22252-22264. doi: 10.1021/jacs.3c08827. Epub 2023 Sep 29. J Am Chem Soc. 2023. PMID: 37773090
Reactive oxygen species-responsive RNA interference.
Rühle J, Klemt I, Abakumova T, Sergeeva O, Vetosheva P, Zatsepin T, Mokhir A. Rühle J, et al. Among authors: klemt i. Chem Commun (Camb). 2022 Mar 31;58(27):4388-4391. doi: 10.1039/d2cc00651k. Chem Commun (Camb). 2022. PMID: 35297916
Synthesis and spectral characterization of the first fluorescein-tagged iron(ii) clathrochelates, their supramolecular interactions with globular proteins, and cellular uptake.
Selin RO, Klemt I, Chernii VY, Losytskyy MY, Chernii S, Mular A, Gumienna-Kontecka E, Kovalska VB, Voloshin YZ, Vologzhanina AV, Dorovatovskii PV, Mokhir A. Selin RO, et al. Among authors: klemt i. RSC Adv. 2021 Feb 22;11(14):8163-8177. doi: 10.1039/d0ra10502c. eCollection 2021 Feb 17. RSC Adv. 2021. PMID: 35423299 Free PMC article.