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A concept of dual-responsive prodrugs based on oligomerization-controlled reactivity of ester groups: an improvement of cancer cells versus neutrophils selectivity of camptothecin.
Klemt I, Reshetnikov V, Dutta S, Bila G, Bilyy R, Cuartero IC, Hidalgo A, Wünsche A, Böhm M, Wondrak M, Kunz-Schughart LA, Tietze R, Beierlein F, Imhof P, Gensberger-Reigl S, Pischetsrieder M, Körber M, Jost T, Mokhir A. Klemt I, et al. Among authors: bilyy r. RSC Med Chem. 2024 Jan 31;15(4):1189-1197. doi: 10.1039/d3md00609c. eCollection 2024 Apr 24. RSC Med Chem. 2024. PMID: 38665843 Free PMC article.
ROS-Responsive N-Alkylaminoferrocenes for Cancer-Cell-Specific Targeting of Mitochondria.
Reshetnikov V, Daum S, Janko C, Karawacka W, Tietze R, Alexiou C, Paryzhak S, Dumych T, Bilyy R, Tripal P, Schmid B, Palmisano R, Mokhir A. Reshetnikov V, et al. Among authors: bilyy r. Angew Chem Int Ed Engl. 2018 Sep 10;57(37):11943-11946. doi: 10.1002/anie.201805955. Epub 2018 Aug 20. Angew Chem Int Ed Engl. 2018. PMID: 30035345
3D-Shaped Binders of Unfolded Proteins Inducing Cancer Cell-Specific Endoplasmic Reticulum Stress In Vitro and In Vivo.
Klemt I, Varzatskii O, Selin R, Vakarov S, Kovalska V, Bila G, Bilyy R, Voloshin Y, Cuartero IC, Hidalgo A, Frey B, Becker I, Friedrich B, Tietze R, Friedrich RP, Alexiou C, Ursu EL, Rotaru A, Solymosi I, Pérez-Ojeda ME, Mokhir A. Klemt I, et al. Among authors: bilyy r. J Am Chem Soc. 2023 Oct 11;145(40):22252-22264. doi: 10.1021/jacs.3c08827. Epub 2023 Sep 29. J Am Chem Soc. 2023. PMID: 37773090
Suppression of neutrophils by sodium exacerbates oxidative stress and arthritis.
Zlatar L, Mahajan A, Muñoz-Becerra M, Weidner D, Bila G, Bilyy R, Titze J, Hoffmann MH, Schett G, Herrmann M, Steffen U, Muñoz LE, Knopf J. Zlatar L, et al. Among authors: bilyy r. Front Immunol. 2023 Aug 2;14:1174537. doi: 10.3389/fimmu.2023.1174537. eCollection 2023. Front Immunol. 2023. PMID: 37600805 Free PMC article.
Lysosome-Targeting Amplifiers of Reactive Oxygen Species as Anticancer Prodrugs.
Daum S, Reshetnikov MSV, Sisa M, Dumych T, Lootsik MD, Bilyy R, Bila E, Janko C, Alexiou C, Herrmann M, Sellner L, Mokhir A. Daum S, et al. Among authors: bilyy r. Angew Chem Int Ed Engl. 2017 Dec 4;56(49):15545-15549. doi: 10.1002/anie.201706585. Epub 2017 Nov 9. Angew Chem Int Ed Engl. 2017. PMID: 28994179
84 results