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ICH S1 prospective evaluation study: weight of evidence approach to predict outcome and value of 2-year rat carcinogenicity studies. A report from the regulatory authorities subgroup.
Bourcier T, McGovern T, Cavaliero T, Ebere G, Nishikawa A, Nishimura J, Ogawa K, Pasanen M, Vespa A, Van der Laan JW. Bourcier T, et al. Among authors: van der laan jw. Front Toxicol. 2024 Apr 11;6:1353783. doi: 10.3389/ftox.2024.1353783. eCollection 2024. Front Toxicol. 2024. PMID: 38665214 Free PMC article.
EMA commentary on the ICH guideline for testing for carcinogenicity of pharmaceuticals.
van der Laan JW, Andersson M, Beken S, Bonelli M, Brendler-Schwaab S, Kane R, Pasanen M, Ponzano S, Paur J, Siezen C, Soleng A, Whomsley R. van der Laan JW, et al. Br J Clin Pharmacol. 2023 Aug;89(8):2341-2348. doi: 10.1111/bcp.15790. Epub 2023 Jun 2. Br J Clin Pharmacol. 2023. PMID: 37265032 No abstract available.
Evaluation of non-clinical toxicity studies of COVID-19 vaccines.
Schilder NKM, Tiesjema B, Theunissen PT, Rengerink KO, van der Laan JW. Schilder NKM, et al. Among authors: van der laan jw. Regul Toxicol Pharmacol. 2023 Aug;142:105438. doi: 10.1016/j.yrtph.2023.105438. Epub 2023 Jun 23. Regul Toxicol Pharmacol. 2023. PMID: 37356612 Free PMC article.
Revision of ICH S8 Needed?
Van Der Laan JW. Van Der Laan JW. Front Toxicol. 2022 Apr 25;4:866737. doi: 10.3389/ftox.2022.866737. eCollection 2022. Front Toxicol. 2022. PMID: 35548682 Free PMC article. No abstract available.
A Collaborative Initiative to Establish Genomic Biomarkers for Assessing Tumorigenic Potential to Reduce Reliance on Conventional Rodent Carcinogenicity Studies.
Corton JC, Mitchell CA, Auerbach S, Bushel P, Ellinger-Ziegelbauer H, Escobar PA, Froetschl R, Harrill AH, Johnson K, Klaunig JE, Pandiri AR, Podtelezhnikov AA, Rager JE, Tanis KQ, van der Laan JW, Vespa A, Yauk CL, Pettit SD, Sistare FD. Corton JC, et al. Among authors: van der laan jw. Toxicol Sci. 2022 Jun 28;188(1):4-16. doi: 10.1093/toxsci/kfac041. Toxicol Sci. 2022. PMID: 35404422 Free PMC article.
Towards a mechanism-based approach for the prediction of nongenotoxic carcinogenic potential of agrochemicals.
Heusinkveld H, Braakhuis H, Gommans R, Botham P, Corvaro M, van der Laan JW, Lewis D, Madia F, Manou I, Schorsch F, Wolterink G, Woutersen R, Corvi R, Mehta J, Luijten M. Heusinkveld H, et al. Among authors: van der laan jw. Crit Rev Toxicol. 2020 Oct;50(9):725-739. doi: 10.1080/10408444.2020.1841732. Epub 2020 Nov 25. Crit Rev Toxicol. 2020. PMID: 33236972 Review.
A comprehensive view on mechanistic approaches for cancer risk assessment of non-genotoxic agrochemicals.
Luijten M, Corvi R, Mehta J, Corvaro M, Delrue N, Felter S, Haas B, Hewitt NJ, Hilton G, Holmes T, Jacobs MN, Jacobs A, Lamplmair F, Lewis D, Madia F, Manou I, Melching-Kollmuss S, Schorsch F, Schütte K, Sewell F, Strupp C, van der Laan JW, Wolf DC, Wolterink G, Woutersen R, Zvonar Z, Heusinkveld H, Braakhuis H. Luijten M, et al. Among authors: van der laan jw. Regul Toxicol Pharmacol. 2020 Dec;118:104789. doi: 10.1016/j.yrtph.2020.104789. Epub 2020 Oct 7. Regul Toxicol Pharmacol. 2020. PMID: 33035627 Free article. Review.
Animal-free applications in the development of cell-based therapies.
van Meer P, Theunissen P, van den Hoorn T, Herberts C, van der Laan JW. van Meer P, et al. Among authors: van der laan jw. Br J Clin Pharmacol. 2021 Jun;87(6):2425-2427. doi: 10.1111/bcp.14544. Epub 2020 Sep 15. Br J Clin Pharmacol. 2021. PMID: 32935350 Free article. No abstract available.
105 results