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The antimicrobial fibupeptide lugdunin forms water-filled channel structures in lipid membranes.
Nat Commun. 2024 Apr 25;15(1):3521. doi: 10.1038/s41467-024-47803-6.
Nat Commun. 2024.
PMID: 38664456
Free PMC article.
Synthetic Lugdunin Analogues Reveal Essential Structural Motifs for Antimicrobial Action and Proton Translocation Capability.
Schilling NA, Berscheid A, Schumacher J, Saur JS, Konnerth MC, Wirtz SN, Beltrán-Beleña JM, Zipperer A, Krismer B, Peschel A, Kalbacher H, Brötz-Oesterhelt H, Steinem C, Grond S.
Schilling NA, et al. Among authors: wirtz sn.
Angew Chem Int Ed Engl. 2019 Jul 1;58(27):9234-9238. doi: 10.1002/anie.201901589. Epub 2019 May 27.
Angew Chem Int Ed Engl. 2019.
PMID: 31059155
Free PMC article.
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Secretion of and Self-Resistance to the Novel Fibupeptide Antimicrobial Lugdunin by Distinct ABC Transporters in Staphylococcus lugdunensis.
Krauss S, Zipperer A, Wirtz S, Saur J, Konnerth MC, Heilbronner S, Torres Salazar BO, Grond S, Krismer B, Peschel A.
Krauss S, et al.
Antimicrob Agents Chemother. 2020 Dec 16;65(1):e01734-20. doi: 10.1128/AAC.01734-20. Print 2020 Dec 16.
Antimicrob Agents Chemother. 2020.
PMID: 33106269
Free PMC article.
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Distinct Lugdunins from a New Efficient Synthesis and Broad Exploitation of Its MRSA-Antimicrobial Structure.
Saur JS, Wirtz SN, Schilling NA, Krismer B, Peschel A, Grond S.
Saur JS, et al. Among authors: wirtz sn.
J Med Chem. 2021 Apr 8;64(7):4034-4058. doi: 10.1021/acs.jmedchem.0c02170. Epub 2021 Mar 29.
J Med Chem. 2021.
PMID: 33779184
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Optimization of imidazole amide derivatives as cannabinoid-1 receptor antagonists for the treatment of obesity.
Smith RA, Fathi Z, Achebe F, Akuche C, Brown SE, Choi S, Fan J, Jenkins S, Kluender HC, Konkar A, Lavoie R, Mays R, Natoli J, O'Connor SJ, Ortiz AA, Su N, Taing C, Tomlinson S, Tritto T, Wang G, Wirtz SN, Wong W, Yang XF, Ying S, Zhang Z.
Smith RA, et al. Among authors: wirtz sn.
Bioorg Med Chem Lett. 2007 May 15;17(10):2706-11. doi: 10.1016/j.bmcl.2007.03.011. Epub 2007 Mar 12.
Bioorg Med Chem Lett. 2007.
PMID: 17383180
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