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Enhancing standard of care chemotherapy efficacy using DNA-dependent protein kinase (DNA-PK) inhibition in preclinical models of Ewing sarcoma.
Collins VJ, Ludwig KR, Nelson AE, Sundara Rajan S, Yeung C, Vulikh K, Isanogle KA, Mendoza A, Difilippantonio S, Karim BO, Caplen NJ, Heske CM. Collins VJ, et al. Among authors: caplen nj. Mol Cancer Ther. 2024 Apr 24. doi: 10.1158/1535-7163.MCT-23-0641. Online ahead of print. Mol Cancer Ther. 2024. PMID: 38657228
Cancer biology functional genomics: From small RNAs to big dreams.
Sundara Rajan S, Ludwig KR, Hall KL, Jones TL, Caplen NJ. Sundara Rajan S, et al. Among authors: caplen nj. Mol Carcinog. 2020 Dec;59(12):1343-1361. doi: 10.1002/mc.23260. Epub 2020 Oct 12. Mol Carcinog. 2020. PMID: 33043516 Free PMC article.
Fusion transcripts: Unexploited vulnerabilities in cancer?
Neckles C, Sundara Rajan S, Caplen NJ. Neckles C, et al. Among authors: caplen nj. Wiley Interdiscip Rev RNA. 2020 Jan;11(1):e1562. doi: 10.1002/wrna.1562. Epub 2019 Aug 13. Wiley Interdiscip Rev RNA. 2020. PMID: 31407506 Free PMC article. Review.
CDK9 Blockade Exploits Context-dependent Transcriptional Changes to Improve Activity and Limit Toxicity of Mithramycin for Ewing Sarcoma.
Flores G, Everett JH, Boguslawski EA, Oswald BM, Madaj ZB, Beddows I, Dikalov S, Adams M, Klumpp-Thomas CA, Kitchen-Goosen SM, Martin SE, Caplen NJ, Helman LJ, Grohar PJ. Flores G, et al. Among authors: caplen nj. Mol Cancer Ther. 2020 May;19(5):1183-1196. doi: 10.1158/1535-7163.MCT-19-0775. Epub 2020 Mar 3. Mol Cancer Ther. 2020. PMID: 32127464 Free PMC article.
Systems-wide RNAi analysis of CASP8AP2/FLASH shows transcriptional deregulation of the replication-dependent histone genes and extensive effects on the transcriptome of colorectal cancer cells.
Hummon AB, Pitt JJ, Camps J, Emons G, Skube SB, Huppi K, Jones TL, Beissbarth T, Kramer F, Grade M, Difilippantonio MJ, Ried T, Caplen NJ. Hummon AB, et al. Among authors: caplen nj. Mol Cancer. 2012 Jan 4;11:1. doi: 10.1186/1476-4598-11-1. Mol Cancer. 2012. PMID: 22216762 Free PMC article.
Cellular inhibition of checkpoint kinase 2 (Chk2) and potentiation of camptothecins and radiation by the novel Chk2 inhibitor PV1019 [7-nitro-1H-indole-2-carboxylic acid {4-[1-(guanidinohydrazone)-ethyl]-phenyl}-amide].
Jobson AG, Lountos GT, Lorenzi PL, Llamas J, Connelly J, Cerna D, Tropea JE, Onda A, Zoppoli G, Kondapaka S, Zhang G, Caplen NJ, Cardellina JH 2nd, Yoo SS, Monks A, Self C, Waugh DS, Shoemaker RH, Pommier Y. Jobson AG, et al. Among authors: caplen nj. J Pharmacol Exp Ther. 2009 Dec;331(3):816-26. doi: 10.1124/jpet.109.154997. Epub 2009 Sep 9. J Pharmacol Exp Ther. 2009. PMID: 19741151 Free PMC article.
83 results