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Condensate-promoting ENL mutation drives tumorigenesis in vivo through dynamic regulation of histone modifications and gene expression.
Cancer Discov. 2024 Apr 24. doi: 10.1158/2159-8290.CD-23-0876. Online ahead of print.
Cancer Discov. 2024.
PMID: 38655899
Hotspot mutations in the structured ENL YEATS domain link aberrant transcriptional condensates and cancer.
Song L, Yao X, Li H, Peng B, Boka AP, Liu Y, Chen G, Liu Z, Mathias KM, Xia L, Li Q, Mir M, Li Y, Li H, Wan L.
Song L, et al. Among authors: mathias km.
Mol Cell. 2022 Nov 3;82(21):4080-4098.e12. doi: 10.1016/j.molcel.2022.09.034. Epub 2022 Oct 21.
Mol Cell. 2022.
PMID: 36272410
Free PMC article.
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Dysregulation of transcriptional condensates in human disease: mechanisms, biological functions, and open questions.
Mathias KM, Liu Y, Wan L.
Mathias KM, et al.
Curr Opin Genet Dev. 2024 May 23;86:102203. doi: 10.1016/j.gde.2024.102203. Online ahead of print.
Curr Opin Genet Dev. 2024.
PMID: 38788489
Review.
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NSD1 mediates antagonism between SWI/SNF and polycomb complexes and is required for transcriptional activation upon EZH2 inhibition.
Drosos Y, Myers JA, Xu B, Mathias KM, Beane EC, Radko-Juettner S, Mobley RJ, Larsen ME, Piccioni F, Ma X, Low J, Hansen BS, Peters ST, Bhanu NV, Dhanda SK, Chen T, Upadhyaya SA, Pruett-Miller SM, Root DE, Garcia BA, Partridge JF, Roberts CWM.
Drosos Y, et al. Among authors: mathias km.
Mol Cell. 2022 Jul 7;82(13):2472-2489.e8. doi: 10.1016/j.molcel.2022.04.015. Epub 2022 May 9.
Mol Cell. 2022.
PMID: 35537449
Free PMC article.
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Rhabdoid Tumors Are Sensitive to the Protein-Translation Inhibitor Homoharringtonine.
Howard TP, Oberlick EM, Rees MG, Arnoff TE, Pham MT, Brenan L, DoCarmo M, Hong AL, Kugener G, Chou HC, Drosos Y, Mathias KM, Ramos P, Seashore-Ludlow B, Giacomelli AO, Wang X, Freeman BB 3rd, Blankenship K, Hoffmann L, Tiv HL, Gokhale PC, Johannessen CM, Stewart EA, Schreiber SL, Hahn WC, Roberts CWM.
Howard TP, et al. Among authors: mathias km.
Clin Cancer Res. 2020 Sep 15;26(18):4995-5006. doi: 10.1158/1078-0432.CCR-19-2717. Epub 2020 Jul 6.
Clin Cancer Res. 2020.
PMID: 32631955
Free PMC article.
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Addressing the stability of C-capped dipeptide efflux pump inhibitors that potentiate the activity of levofloxacin in Pseudomonas aeruginosa.
Renau TE, Léger R, Flamme EM, She MW, Gannon CL, Mathias KM, Lomovskaya O, Chamberland S, Lee VJ, Ohta T, Nakayama K, Ishida Y.
Renau TE, et al. Among authors: mathias km.
Bioorg Med Chem Lett. 2001 Mar 12;11(5):663-7. doi: 10.1016/s0960-894x(01)00033-6.
Bioorg Med Chem Lett. 2001.
PMID: 11266165
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