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Targeting PRL phosphatases in hematological malignancies.
Xiao S, Chen H, Bai Y, Zhang ZY, Liu Y. Xiao S, et al. Among authors: chen h. Expert Opin Ther Targets. 2024 Apr;28(4):259-271. doi: 10.1080/14728222.2024.2344695. Epub 2024 Apr 26. Expert Opin Ther Targets. 2024. PMID: 38653737 Review.
PRL2 phosphatase enhances oncogenic FLT3 signaling via dephosphorylation of the E3 ubiquitin ligase CBL at tyrosine 371.
Chen H, Bai Y, Kobayashi M, Xiao S, Cai W, Barajas S, Chen S, Miao J, Meke FN, Vemula S, Ropa JP, Croop JM, Boswell HS, Wan J, Jia Y, Liu H, Li LS, Altman JK, Eklund EA, Ji P, Tong W, Band H, Huang DT, Platanias LC, Zhang ZY, Liu Y. Chen H, et al. Among authors: chen s. Blood. 2023 Jan 19;141(3):244-259. doi: 10.1182/blood.2022016580. Blood. 2023. PMID: 36206490 Free PMC article.
PRL2 Phosphatase Promotes Oncogenic KIT Signaling in Leukemia Cells through Modulating CBL Phosphorylation.
Chen H, Bai Y, Kobayashi M, Xiao S, Barajas S, Cai W, Chen S, Miao J, Nguele Meke F, Yao C, Yang Y, Strube K, Satchivi O, Sun J, Rönnstrand L, Croop JM, Boswell HS, Jia Y, Liu H, Li LS, Altman JK, Eklund EA, Sukhanova M, Ji P, Tong W, Band H, Huang DT, Platanias LC, Zhang ZY, Liu Y. Chen H, et al. Among authors: chen s. Mol Cancer Res. 2024 Jan 2;22(1):94-103. doi: 10.1158/1541-7786.MCR-23-0115. Mol Cancer Res. 2024. PMID: 37756563
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