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Clinical mutations in the TERT and TERC genes coding for telomerase components induced oxidative stress, DNA damage at telomeres and cell apoptosis besides decreased telomerase activity.
Fernández-Varas B, Manguan-García C, Rodriguez-Centeno J, Mendoza-Lupiáñez L, Calatayud J, Perona R, Martín-Martínez M, Gutierrez-Rodriguez M, Benítez-Buelga C, Sastre L. Fernández-Varas B, et al. Among authors: sastre l. Hum Mol Genet. 2024 Apr 18;33(9):818-834. doi: 10.1093/hmg/ddae015. Hum Mol Genet. 2024. PMID: 38641551 Free PMC article.
GSE4, a Small Dyskerin- and GSE24.2-Related Peptide, Induces Telomerase Activity, Cell Proliferation and Reduces DNA Damage, Oxidative Stress and Cell Senescence in Dyskerin Mutant Cells.
Iarriccio L, Manguán-García C, Pintado-Berninches L, Mancheño JM, Molina A, Perona R, Sastre L. Iarriccio L, et al. Among authors: sastre l. PLoS One. 2015 Nov 16;10(11):e0142980. doi: 10.1371/journal.pone.0142980. eCollection 2015. PLoS One. 2015. PMID: 26571381 Free PMC article.
Mutations in XLF/NHEJ1/Cernunnos gene results in downregulation of telomerase genes expression and telomere shortening.
Carrillo J, Calvete O, Pintado-Berninches L, Manguan-García C, Sevilla Navarro J, Arias-Salgado EG, Sastre L, Guenechea G, López Granados E, de Villartay JP, Revy P, Benitez J, Perona R. Carrillo J, et al. Among authors: sastre l. Hum Mol Genet. 2017 May 15;26(10):1900-1914. doi: 10.1093/hmg/ddx098. Hum Mol Genet. 2017. PMID: 28369633
Expression of the genetic suppressor element 24.2 (GSE24.2) decreases DNA damage and oxidative stress in X-linked dyskeratosis congenita cells.
Manguan-Garcia C, Pintado-Berninches L, Carrillo J, Machado-Pinilla R, Sastre L, Pérez-Quilis C, Esmoris I, Gimeno A, García-Giménez JL, Pallardó FV, Perona R. Manguan-Garcia C, et al. Among authors: sastre l. PLoS One. 2014 Jul 2;9(7):e101424. doi: 10.1371/journal.pone.0101424. eCollection 2014. PLoS One. 2014. PMID: 24987982 Free PMC article.
GSE4 peptide suppresses oxidative and telomere deficiencies in ataxia telangiectasia patient cells.
Pintado-Berninches L, Fernandez-Varas B, Benitez-Buelga C, Manguan-Garcia C, Serrano-Benitez A, Iarriccio L, Carrillo J, Guenechea G, Egusquiaguirre SP, Pedraz JL, Hernández RM, Igartua M, Arias-Salgado EG, Cortés-Ledesma F, Sastre L, Perona R. Pintado-Berninches L, et al. Among authors: sastre l. Cell Death Differ. 2019 Oct;26(10):1998-2014. doi: 10.1038/s41418-018-0272-7. Epub 2019 Jan 22. Cell Death Differ. 2019. PMID: 30670828 Free PMC article.
GSE4-loaded nanoparticles a potential therapy for lung fibrosis that enhances pneumocyte growth, reduces apoptosis and DNA damage.
Pintado-Berninches L, Montes-Worboys A, Manguan-García C, Arias-Salgado EG, Serrano A, Fernandez-Varas B, Guerrero-López R, Iarriccio L, Planas L, Guenechea G, Egusquiaguirre SP, Hernandez RM, Igartua M, Luis Pedraz J, Cortijo J, Sastre L, Molina-Molina M, Perona R. Pintado-Berninches L, et al. Among authors: sastre l. FASEB J. 2021 Mar;35(3):e21422. doi: 10.1096/fj.202001160RR. FASEB J. 2021. PMID: 33638895 Free article.
110 results