Spechler SJ - Search Results

1

Hypoxia-inducible factor-1α mediates reflux-induced epithelial-mesenchymal plasticity in Barrett's oesophagus patients.

Zhang Q, Dunbar KB, Odze RD, Agoston AT, Wang X, Su T, Nguyen AD, Zhang X, Spechler SJ, Souza RF. Zhang Q, et al. Among authors: spechler sj. Gut. 2024 Apr 19:gutjnl-2023-331467. doi: 10.1136/gutjnl-2023-331467. Online ahead of print. Gut. 2024. PMID: 38641363

2

Omeprazole blocks eotaxin-3 expression by oesophageal squamous cells from patients with eosinophilic oesophagitis and GORD.

Cheng E, Zhang X, Huo X, Yu C, Zhang Q, Wang DH, Spechler SJ, Souza RF. Cheng E, et al. Among authors: spechler sj. Gut. 2013 Jun;62(6):824-32. doi: 10.1136/gutjnl-2012-302250. Epub 2012 May 12. Gut. 2013. PMID: 22580413 Free PMC article.

3

In oesophageal squamous cells exposed to acidic bile salt medium, omeprazole inhibits IL-8 expression through effects on nuclear factor-κB and activator protein-1.

Huo X, Zhang X, Yu C, Zhang Q, Cheng E, Wang DH, Pham TH, Spechler SJ, Souza RF. Huo X, et al. Among authors: spechler sj. Gut. 2014 Jul;63(7):1042-52. doi: 10.1136/gutjnl-2013-305533. Epub 2013 Sep 18. Gut. 2014. PMID: 24048734 Free PMC article.

4

In oesophageal squamous cells, nitric oxide causes S-nitrosylation of Akt and blocks SOX2 (sex determining region Y-box 2) expression.

Asanuma K, Huo X, Agoston A, Zhang X, Yu C, Cheng E, Zhang Q, Dunbar KB, Pham TH, Wang DH, Iijima K, Shimosegawa T, Odze RD, Spechler SJ, Souza RF. Asanuma K, et al. Among authors: spechler sj. Gut. 2016 Sep;65(9):1416-26. doi: 10.1136/gutjnl-2015-309272. Epub 2015 May 18. Gut. 2016. PMID: 25986942 Free PMC article.

5

Hypoxia-inducible factor-2α plays a role in mediating oesophagitis in GORD.

Huo X, Agoston AT, Dunbar KB, Cipher DJ, Zhang X, Yu C, Cheng E, Zhang Q, Pham TH, Tambar UK, Bruick RK, Wang DH, Odze RD, Spechler SJ, Souza RF. Huo X, et al. Among authors: spechler sj. Gut. 2017 Sep;66(9):1542-1554. doi: 10.1136/gutjnl-2016-312595. Epub 2016 Sep 30. Gut. 2017. PMID: 27694141 Free PMC article. Clinical Trial.

6

Aspirin prevents NF-κB activation and CDX2 expression stimulated by acid and bile salts in oesophageal squamous cells of patients with Barrett's oesophagus.

Huo X, Zhang X, Yu C, Cheng E, Zhang Q, Dunbar KB, Pham TH, Lynch JP, Wang DH, Bresalier RS, Spechler SJ, Souza RF. Huo X, et al. Among authors: spechler sj. Gut. 2018 Apr;67(4):606-615. doi: 10.1136/gutjnl-2016-313584. Epub 2017 Apr 25. Gut. 2018. PMID: 28442495 Free PMC article.

7

Mechanisms and pathophysiology of Barrett oesophagus.

Souza RF, Spechler SJ. Souza RF, et al. Among authors: spechler sj. Nat Rev Gastroenterol Hepatol. 2022 Sep;19(9):605-620. doi: 10.1038/s41575-022-00622-w. Epub 2022 Jun 7. Nat Rev Gastroenterol Hepatol. 2022. PMID: 35672395 Review.

8

Hallmarks of cancer progression in Barrett's oesophagus.

Morales CP, Souza RF, Spechler SJ. Morales CP, et al. Among authors: spechler sj. Lancet. 2002 Nov 16;360(9345):1587-9. doi: 10.1016/S0140-6736(02)11569-8. Lancet. 2002. PMID: 12443613 Review.

9

Barrett's esophagus: chemoprevention.

Souza RF, Spechler SJ. Souza RF, et al. Among authors: spechler sj. Gastrointest Endosc Clin N Am. 2003 Jul;13(3):419-32. doi: 10.1016/s1052-5157(03)00039-4. Gastrointest Endosc Clin N Am. 2003. PMID: 14629099 Review.

10

Acid has antiproliferative effects in nonneoplastic Barrett's epithelial cells.

Feagins LA, Zhang HY, Hormi-Carver K, Quinones MH, Thomas D, Zhang X, Terada LS, Spechler SJ, Ramirez RD, Souza RF. Feagins LA, et al. Among authors: spechler sj. Am J Gastroenterol. 2007 Jan;102(1):10-20. doi: 10.1111/j.1572-0241.2006.01005.x. Am J Gastroenterol. 2007. PMID: 17266684

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