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Bioequivalence risk assessment of oral formulations containing racemic ibuprofen through a chiral physiologically based pharmacokinetic model of ibuprofen enantiomers.
Eur J Pharm Biopharm. 2024 Jun;199:114293. doi: 10.1016/j.ejpb.2024.114293. Epub 2024 Apr 17.
Eur J Pharm Biopharm. 2024.
PMID: 38641229
Free article.
Phys-DAT: A physiologically-based pharmacokinetic model for unraveling the dissolution, transit and absorption processes using PhysPK®.
Cuquerella-Gilabert M, Reig-López J, Serna J, Rueda-Ferreiro A, Merino-Sanjuan M, Mangas-Sanjuan V, Sánchez-Herrero S.
Cuquerella-Gilabert M, et al. Among authors: reig lopez j.
Comput Methods Programs Biomed. 2024 Jan;243:107929. doi: 10.1016/j.cmpb.2023.107929. Epub 2023 Nov 18.
Comput Methods Programs Biomed. 2024.
PMID: 38006685
Free article.
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Application of population physiologically based pharmacokinetic modelling to optimize target expression and clearance mechanisms of therapeutic monoclonal antibodies.
Reig-Lopez J, Tang W, Fernandez-Teruel C, Merino-Sanjuan M, Mangas-Sanjuan V, Boulton DW, Sharma P.
Reig-Lopez J, et al.
Br J Clin Pharmacol. 2023 Sep;89(9):2691-2702. doi: 10.1111/bcp.15745. Epub 2023 May 1.
Br J Clin Pharmacol. 2023.
PMID: 37055941
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A physiologically based pharmacokinetic model for open acid and lactone forms of atorvastatin and metabolites to assess the drug-gene interaction with SLCO1B1 polymorphisms.
Reig-López J, Merino-Sanjuan M, García-Arieta A, Mangas-Sanjuán V.
Reig-López J, et al.
Biomed Pharmacother. 2022 Dec;156:113914. doi: 10.1016/j.biopha.2022.113914. Epub 2022 Oct 26.
Biomed Pharmacother. 2022.
PMID: 36306592
Free article.
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Current Evidence, Challenges, and Opportunities of Physiologically Based Pharmacokinetic Models of Atorvastatin for Decision Making.
Reig-López J, García-Arieta A, Mangas-Sanjuán V, Merino-Sanjuán M.
Reig-López J, et al.
Pharmaceutics. 2021 May 13;13(5):709. doi: 10.3390/pharmaceutics13050709.
Pharmaceutics. 2021.
PMID: 34068030
Free PMC article.
Review.
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Physiologically-Based Pharmacokinetic/Pharmacodynamic Model of MBQ-167 to Predict Tumor Growth Inhibition in Mice.
Reig-López J, Maldonado MDM, Merino-Sanjuan M, Cruz-Collazo AM, Ruiz-Calderón JF, Mangas-Sanjuán V, Dharmawardhane S, Duconge J.
Reig-López J, et al.
Pharmaceutics. 2020 Oct 15;12(10):975. doi: 10.3390/pharmaceutics12100975.
Pharmaceutics. 2020.
PMID: 33076517
Free PMC article.
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A multilevel object-oriented modelling methodology for physiologically-based pharmacokinetics (PBPK): Evaluation with a semi-mechanistic pharmacokinetic model.
Reig-Lopez J, Merino-Sanjuan M, Mangas-Sanjuan V, Prado-Velasco M.
Reig-Lopez J, et al.
Comput Methods Programs Biomed. 2020 Jun;189:105322. doi: 10.1016/j.cmpb.2020.105322. Epub 2020 Jan 9.
Comput Methods Programs Biomed. 2020.
PMID: 31954235
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