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Gut-associated lymphoid tissue attrition associates with response to anti-α4β7 therapy in ulcerative colitis.
Canales-Herrerias P, Uzzan M, Seki A, Czepielewski RS, Verstockt B, Livanos AE, Raso F, Dunn A, Dai D, Wang A, Al-Taie Z, Martin J, Laurent T, Ko HM, Tokuyama M, Tankelevich M, Meringer H, Cossarini F, Jha D, Krek A, Paulsen JD, Taylor MD, Nakadar MZ, Wong J, Erlich EC, Mintz RL, Onufer EJ, Helmink BA, Sharma K, Rosenstein A, Ganjian D, Chung G, Dawson T, Juarez J, Yajnik V, Cerutti A, Faith JJ, Suarez-Farinas M, Argmann C, Petralia F, Randolph GJ, Polydorides AD, Reboldi A, Colombel JF, Mehandru S. Canales-Herrerias P, et al. Among authors: mehandru s. Sci Immunol. 2024 Apr 19;9(94):eadg7549. doi: 10.1126/sciimmunol.adg7549. Epub 2024 Apr 19. Sci Immunol. 2024. PMID: 38640252
Gut-associated lymphoid tissue attrition associates with response to anti-α4β7 therapy in ulcerative colitis.
Canales-Herrerias P, Uzzan M, Seki A, Czepielewski RS, Verstockt B, Livanos A, Raso F, Dunn A, Dai D, Wang A, Al-Taie Z, Martin J, Ko HM, Tokuyama M, Tankelevich M, Meringer H, Cossarini F, Jha D, Krek A, Paulsen JD, Nakadar MZ, Wong J, Erlich EC, Onufer EJ, Helmink BA, Sharma K, Rosenstein A, Chung G, Dawson T, Juarez J, Yajnik V, Cerutti A, Faith J, Suarez-Farinas M, Argmann C, Petralia F, Randolph GJ, Polydorides AD, Reboldi A, Colombel JF, Mehandru S. Canales-Herrerias P, et al. Among authors: mehandru s. bioRxiv [Preprint]. 2023 Jan 20:2023.01.19.524731. doi: 10.1101/2023.01.19.524731. bioRxiv. 2023. PMID: 36711839 Free PMC article. Updated. Preprint.
Ulcerative colitis is characterized by a plasmablast-skewed humoral response associated with disease activity.
Uzzan M, Martin JC, Mesin L, Livanos AE, Castro-Dopico T, Huang R, Petralia F, Magri G, Kumar S, Zhao Q, Rosenstein AK, Tokuyama M, Sharma K, Ungaro R, Kosoy R, Jha D, Fischer J, Singh H, Keir ME, Ramamoorthi N, O'Gorman WE, Cohen BL, Rahman A, Cossarini F, Seki A, Leyre L, Vaquero ST, Gurunathan S, Grasset EK, Losic B, Dubinsky M, Greenstein AJ, Gottlieb Z, Legnani P, George J, Irizar H, Stojmirovic A, Brodmerkel C, Kasarkis A, Sands BE, Furtado G, Lira SA, Tuong ZK, Ko HM, Cerutti A, Elson CO, Clatworthy MR, Merad M, Suárez-Fariñas M, Argmann C, Hackney JA, Victora GD, Randolph GJ, Kenigsberg E, Colombel JF, Mehandru S. Uzzan M, et al. Among authors: mehandru s. Nat Med. 2022 Apr;28(4):766-779. doi: 10.1038/s41591-022-01680-y. Epub 2022 Feb 21. Nat Med. 2022. PMID: 35190725 Free PMC article.
Myeloid cell influx into the colonic epithelium is associated with disease severity and non-response to anti-Tumor Necrosis Factor Therapy in patients with Ulcerative Colitis.
Jha D, Al-Taie Z, Krek A, Eshghi ST, Fantou A, Laurent T, Tankelevich M, Cao X, Meringer H, Livanos AE, Tokuyama M, Cossarini F, Bourreille A, Josien R, Hou R, Canales-Herrerias P, Ungaro RC, Kayal M, Marion J, Polydorides AD, Ko HM, D'souza D, Merand R, Kim-Schulze S, Hackney JA, Nguyen A, McBride JM, Yuan GC, Colombel JF, Martin JC, Argmann C, Suárez-Fariñas M, Petralia F, Mehandru S. Jha D, et al. Among authors: mehandru s. bioRxiv [Preprint]. 2023 Jun 5:2023.06.02.542863. doi: 10.1101/2023.06.02.542863. bioRxiv. 2023. PMID: 37333091 Free PMC article. Preprint.
The appendix and ulcerative colitis - an unsolved connection.
Agrawal M, Allin KH, Mehandru S, Faith J, Jess T, Colombel JF. Agrawal M, et al. Among authors: mehandru s. Nat Rev Gastroenterol Hepatol. 2023 Sep;20(9):615-624. doi: 10.1038/s41575-023-00774-3. Epub 2023 Apr 20. Nat Rev Gastroenterol Hepatol. 2023. PMID: 37081213 Free PMC article. Review.
Immune cell therapy in IBD.
Dunkin D, Mehandru S, Colombel JF. Dunkin D, et al. Among authors: mehandru s. Dig Dis. 2014;32 Suppl 1:61-6. doi: 10.1159/000367827. Epub 2014 Dec 17. Dig Dis. 2014. PMID: 25531354 Review.
Ulcerative colitis.
Ungaro R, Mehandru S, Allen PB, Peyrin-Biroulet L, Colombel JF. Ungaro R, et al. Among authors: mehandru s. Lancet. 2017 Apr 29;389(10080):1756-1770. doi: 10.1016/S0140-6736(16)32126-2. Epub 2016 Dec 1. Lancet. 2017. PMID: 27914657 Free PMC article. Review.
127 results