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Liver-targeted polymeric prodrugs delivered subcutaneously improve tafenoquine therapeutic window for malaria radical cure.
Sci Adv. 2024 Apr 19;10(16):eadk4492. doi: 10.1126/sciadv.adk4492. Epub 2024 Apr 19.
Sci Adv. 2024.
PMID: 38640243
Free PMC article.
Liver-targeted polymeric prodrugs of 8-aminoquinolines for malaria radical cure.
Srinivasan S, Roy D, Chavas TEJ, Vlaskin V, Ho DK, Pottenger A, LeGuyader CLM, Maktabi M, Strauch P, Jackson C, Flaherty SM, Lin H, Zhang J, Pybus B, Li Q, Huber HE, Burke PA, Wesche D, Rochford R, Stayton PS.
Srinivasan S, et al. Among authors: chavas tej.
J Control Release. 2021 Mar 10;331:213-227. doi: 10.1016/j.jconrel.2020.12.046. Epub 2020 Dec 27.
J Control Release. 2021.
PMID: 33378692
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A macrophage-targeted platform for extending drug dosing with polymer prodrugs for pulmonary infection prophylaxis.
Chavas TEJ, Su FY, Srinivasan S, Roy D, Lee B, Lovelace-Macon L, Rerolle GF, Limqueco E, Skerrett SJ, Ratner DM, West TE, Stayton PS.
Chavas TEJ, et al.
J Control Release. 2021 Feb 10;330:284-292. doi: 10.1016/j.jconrel.2020.11.031. Epub 2020 Nov 19.
J Control Release. 2021.
PMID: 33221351
Free PMC article.
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Fully synthetic injectable depots with high drug content and tunable pharmacokinetics for long-acting drug delivery.
Ho DK, LeGuyader C, Srinivasan S, Roy D, Vlaskin V, Chavas TEJ, Lopez CL, Snyder JM, Postma A, Chiefari J, Stayton PS.
Ho DK, et al. Among authors: chavas tej.
J Control Release. 2021 Jan 10;329:257-269. doi: 10.1016/j.jconrel.2020.11.030. Epub 2020 Nov 18.
J Control Release. 2021.
PMID: 33217474
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Unbiased Mass Spectrometry Elucidation of the Targets and Mechanisms of Activity-Based Probes: A Case Study Involving Sulfonyl Fluorides.
Chavas TEJ, Fuchter MJ, DiMaggio PA Jr.
Chavas TEJ, et al.
ACS Chem Biol. 2018 Oct 19;13(10):2897-2907. doi: 10.1021/acschembio.8b00530. Epub 2018 Sep 25.
ACS Chem Biol. 2018.
PMID: 30192509
Free article.
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Biarylphosphonite gold(I) complexes as superior catalysts for oxidative cyclization of propynyl arenes into indan-2-ones.
Henrion G, Chavas TE, Le Goff X, Gagosz F.
Henrion G, et al.
Angew Chem Int Ed Engl. 2013 Jun 10;52(24):6277-82. doi: 10.1002/anie.201301015. Epub 2013 May 6.
Angew Chem Int Ed Engl. 2013.
PMID: 23649595
No abstract available.
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