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TANGO1 inhibitors reduce collagen secretion and limit tissue scarring.
Raote I, Rosendahl AH, Häkkinen HM, Vibe C, Küçükaylak I, Sawant M, Keufgens L, Frommelt P, Halwas K, Broadbent K, Cunquero M, Castro G, Villemeur M, Nüchel J, Bornikoel A, Dam B, Zirmire RK, Kiran R, Carolis C, Andilla J, Loza-Alvarez P, Ruprecht V, Jamora C, Campelo F, Krüger M, Hammerschmidt M, Eckes B, Neundorf I, Krieg T, Malhotra V. Raote I, et al. Among authors: ruprecht v. Nat Commun. 2024 Apr 24;15(1):3302. doi: 10.1038/s41467-024-47004-1. Nat Commun. 2024. PMID: 38658535 Free PMC article.
Membrane to cortex attachment determines different mechanical phenotypes in LGR5+ and LGR5- colorectal cancer cells.
Conti S, Venturini V, Cañellas-Socias A, Cortina C, Abenza JF, Stephan-Otto Attolini C, Middendorp Guerra E, Xu CK, Li JH, Rossetti L, Stassi G, Roca-Cusachs P, Diz-Muñoz A, Ruprecht V, Guck J, Batlle E, Labernadie A, Trepat X. Conti S, et al. Among authors: ruprecht v. Nat Commun. 2024 Apr 18;15(1):3363. doi: 10.1038/s41467-024-47227-2. Nat Commun. 2024. PMID: 38637494 Free PMC article.
Specialization of the photoreceptor transcriptome by Srrm3-dependent microexons is required for outer segment maintenance and vision.
Ciampi L, Mantica F, López-Blanch L, Permanyer J, Rodriguez-Marín C, Zang J, Cianferoni D, Jiménez-Delgado S, Bonnal S, Miravet-Verde S, Ruprecht V, Neuhauss SCF, Banfi S, Carrella S, Serrano L, Head SA, Irimia M. Ciampi L, et al. Among authors: ruprecht v. Proc Natl Acad Sci U S A. 2022 Jul 19;119(29):e2117090119. doi: 10.1073/pnas.2117090119. Epub 2022 Jul 12. Proc Natl Acad Sci U S A. 2022. PMID: 35858306 Free PMC article.
Cooperative epithelial phagocytosis enables error correction in the early embryo.
Hoijman E, Häkkinen HM, Tolosa-Ramon Q, Jiménez-Delgado S, Wyatt C, Miret-Cuesta M, Irimia M, Callan-Jones A, Wieser S, Ruprecht V. Hoijman E, et al. Among authors: ruprecht v. Nature. 2021 Feb;590(7847):618-623. doi: 10.1038/s41586-021-03200-3. Epub 2021 Feb 10. Nature. 2021. PMID: 33568811
The nucleus measures shape changes for cellular proprioception to control dynamic cell behavior.
Venturini V, Pezzano F, Català Castro F, Häkkinen HM, Jiménez-Delgado S, Colomer-Rosell M, Marro M, Tolosa-Ramon Q, Paz-López S, Valverde MA, Weghuber J, Loza-Alvarez P, Krieg M, Wieser S, Ruprecht V. Venturini V, et al. Among authors: ruprecht v. Science. 2020 Oct 16;370(6514):eaba2644. doi: 10.1126/science.aba2644. Science. 2020. PMID: 33060331
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