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The novel small molecule E0924G dually regulates bone formation and bone resorption through activating the PPARδ signaling pathway to prevent bone loss in ovariectomized rats and senile mice.
Li Y, Liu C, Han X, Sheng R, Bao L, Lei L, Wu Y, Li Q, Zhang Y, Zhang J, Wang W, Zhang Y, Li S, Wang C, Wei X, Wang J, Peng Z, Xu Y, Si S. Li Y, et al. Among authors: wu y. Bioorg Chem. 2024 Jun;147:107364. doi: 10.1016/j.bioorg.2024.107364. Epub 2024 Apr 11. Bioorg Chem. 2024. PMID: 38636434
A pan-PPAR agonist E17241 ameliorates hyperglycemia and diabetic dyslipidemia in KKAy mice via up-regulating ABCA1 in islet, liver, and white adipose tissue.
Sheng R, Li Y, Wu Y, Liu C, Wang W, Han X, Li Y, Lei L, Jiang X, Zhang Y, Zhang Y, Li S, Hong B, Liu C, Xu Y, Si S. Sheng R, et al. Among authors: wu y. Biomed Pharmacother. 2024 Mar;172:116220. doi: 10.1016/j.biopha.2024.116220. Epub 2024 Feb 2. Biomed Pharmacother. 2024. PMID: 38308968 Free article.
A new trichostatin analog from Streptomyces sp. CPCC 203909.
Chen MH, Wu YX, Xu YN, Liu P, Yu LY, Hong B, Jiang W, Si SY. Chen MH, et al. J Asian Nat Prod Res. 2015;17(6):676-82. doi: 10.1080/10286020.2015.1042372. Epub 2015 May 15. J Asian Nat Prod Res. 2015. PMID: 25977996
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