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The novel small molecule E0924G dually regulates bone formation and bone resorption through activating the PPARδ signaling pathway to prevent bone loss in ovariectomized rats and senile mice.
Li Y, Liu C, Han X, Sheng R, Bao L, Lei L, Wu Y, Li Q, Zhang Y, Zhang J, Wang W, Zhang Y, Li S, Wang C, Wei X, Wang J, Peng Z, Xu Y, Si S. Li Y, et al. Among authors: si s. Bioorg Chem. 2024 Jun;147:107364. doi: 10.1016/j.bioorg.2024.107364. Epub 2024 Apr 11. Bioorg Chem. 2024. PMID: 38636434
Substituted benzothiophene or benzofuran derivatives as a novel class of bone morphogenetic protein-2 up-regulators: synthesis, structure-activity relationships, and preventive bone loss efficacies in senescence accelerated mice (SAMP6) and ovariectomized rats.
Guo HF, Shao HY, Yang ZY, Xue ST, Li X, Liu ZY, He XB, Jiang JD, Zhang YQ, Si SY, Li ZR. Guo HF, et al. J Med Chem. 2010 Feb 25;53(4):1819-29. doi: 10.1021/jm901685n. J Med Chem. 2010. PMID: 20088515
695 results