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Rapid Metabolism Underlying Subtherapeutic Serum Levels of Atypical Antipsychotics Preceding Clozapine Treatment: A Retrospective Analysis of Real-World Data.
CNS Drugs. 2024 Jun;38(6):473-480. doi: 10.1007/s40263-024-01079-y. Epub 2024 Apr 18.
CNS Drugs. 2024.
PMID: 38635089
Free PMC article.
Impact of NFIB and CYP1A variants on clozapine serum concentration-A retrospective naturalistic cohort study on 526 patients with known smoking habits.
Lenk HÇ, Løvsletten Smith R, O'Connell KS, Jukić MM, Kringen MK, Andreassen OA, Ingelman-Sundberg M, Molden E.
Lenk HÇ, et al.
Clin Transl Sci. 2023 Jan;16(1):62-72. doi: 10.1111/cts.13422. Epub 2022 Oct 7.
Clin Transl Sci. 2023.
PMID: 36152308
Free PMC article.
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Polygenic overlap with body-mass index improves prediction of treatment-resistant schizophrenia.
O'Connell KS, Koch E, Lenk HÇ, Akkouh IA, Hindley G, Jaholkowski P, Smith RL, Holen B, Shadrin AA, Frei O, Smeland OB, Steen NE, Dale AM, Molden E, Djurovic S, Andreassen OA.
O'Connell KS, et al. Among authors: lenk hc.
Psychiatry Res. 2023 Jul;325:115217. doi: 10.1016/j.psychres.2023.115217. Epub 2023 Apr 23.
Psychiatry Res. 2023.
PMID: 37146461
Free PMC article.
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Effect of the NFIB rs28379954 T>C polymorphism on CYP2D6-catalyzed metabolism of solanidine.
Smith RL, Wollmann BM, Størset E, Lenk HÇ, O'Connell KS, Kristiansen MK, Ingelman-Sundberg M, Molden E.
Smith RL, et al. Among authors: lenk hc.
Clin Transl Sci. 2024 Feb;17(2):e13743. doi: 10.1111/cts.13743.
Clin Transl Sci. 2024.
PMID: 38385986
Free PMC article.
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The Polymorphic Nuclear Factor NFIB Regulates Hepatic CYP2D6 Expression and Influences Risperidone Metabolism in Psychiatric Patients.
Lenk HÇ, Klöditz K, Johansson I, Smith RL, Jukić MM, Molden E, Ingelman-Sundberg M.
Lenk HÇ, et al.
Clin Pharmacol Ther. 2022 May;111(5):1165-1174. doi: 10.1002/cpt.2571. Epub 2022 Mar 20.
Clin Pharmacol Ther. 2022.
PMID: 35253216
Free PMC article.
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