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The Effect of Alzheimer's Disease-Associated Genetic Variants on Longevity.
Tesi N, Hulsman M, van der Lee SJ, Jansen IE, Stringa N, van Schoor NM, Scheltens P, van der Flier WM, Huisman M, Reinders MJT, Holstege H. Tesi N, et al. Among authors: holstege h. Front Genet. 2021 Dec 21;12:748781. doi: 10.3389/fgene.2021.748781. eCollection 2021. Front Genet. 2021. PMID: 34992629 Free PMC article.
The correlation between neuropathology levels and cognitive performance in centenarians.
Zhang M, Ganz AB, Rohde S, Lorenz L, Rozemuller AJM, van Vliet K, Graat M, Sikkes SAM, Reinders MJT, Scheltens P, Hulsman M, Hoozemans JJM, Holstege H. Zhang M, et al. Among authors: holstege h. Alzheimers Dement. 2023 Nov;19(11):5036-5047. doi: 10.1002/alz.13087. Epub 2023 Apr 24. Alzheimers Dement. 2023. PMID: 37092333
Alzheimer's disease risk variants modulate endophenotypes in mild cognitive impairment.
Louwersheimer E, Wolfsgruber S, Espinosa A, Lacour A, Heilmann-Heimbach S, Alegret M, Hernández I, Rosende-Roca M, Tárraga L, Boada M, Kornhuber J, Peters O, Frölich L, Hüll M, Rüther E, Wiltfang J, Scherer M, Riedel-Heller S, Jessen F, Nöthen MM, Maier W, Koene T, Scheltens P, Holstege H, Wagner M, Ruiz A, van der Flier WM, Becker T, Ramirez A. Louwersheimer E, et al. Among authors: holstege h. Alzheimers Dement. 2016 Aug;12(8):872-81. doi: 10.1016/j.jalz.2016.01.006. Epub 2016 Feb 26. Alzheimers Dement. 2016. PMID: 26921674 Free article.
Rare Genetic Variant in SORL1 May Increase Penetrance of Alzheimer's Disease in a Family with Several Generations of APOE-ɛ4 Homozygosity.
Louwersheimer E, Cohn-Hokke PE, Pijnenburg YA, Weiss MM, Sistermans EA, Rozemuller AJ, Hulsman M, van Swieten JC, van Duijn CM, Barkhof F, Koene T, Scheltens P, Van der Flier WM, Holstege H. Louwersheimer E, et al. Among authors: holstege h. J Alzheimers Dis. 2017;56(1):63-74. doi: 10.3233/JAD-160091. J Alzheimers Dis. 2017. PMID: 27911290 Free PMC article.
Characterization of pathogenic SORL1 genetic variants for association with Alzheimer's disease: a clinical interpretation strategy.
Holstege H, van der Lee SJ, Hulsman M, Wong TH, van Rooij JG, Weiss M, Louwersheimer E, Wolters FJ, Amin N, Uitterlinden AG, Hofman A, Ikram MA, van Swieten JC, Meijers-Heijboer H, van der Flier WM, Reinders MJ, van Duijn CM, Scheltens P. Holstege H, et al. Eur J Hum Genet. 2017 Aug;25(8):973-981. doi: 10.1038/ejhg.2017.87. Epub 2017 May 24. Eur J Hum Genet. 2017. PMID: 28537274 Free PMC article.
Centenarian controls increase variant effect sizes by an average twofold in an extreme case-extreme control analysis of Alzheimer's disease.
Tesi N, van der Lee SJ, Hulsman M, Jansen IE, Stringa N, van Schoor N, Meijers-Heijboer H, Huisman M, Scheltens P, Reinders MJT, van der Flier WM, Holstege H. Tesi N, et al. Among authors: holstege h. Eur J Hum Genet. 2019 Feb;27(2):244-253. doi: 10.1038/s41431-018-0273-5. Epub 2018 Sep 26. Eur J Hum Genet. 2019. PMID: 30258121 Free PMC article.
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