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DNA double-strand break-capturing nuclear envelope tubules drive DNA repair.
Shokrollahi M, Stanic M, Hundal A, Chan JNY, Urman D, Jordan CA, Hakem A, Espin R, Hao J, Krishnan R, Maass PG, Dickson BC, Hande MP, Pujana MA, Hakem R, Mekhail K. Shokrollahi M, et al. Among authors: chan jny. Nat Struct Mol Biol. 2024 Apr 17. doi: 10.1038/s41594-024-01286-7. Online ahead of print. Nat Struct Mol Biol. 2024. PMID: 38632359
Nucleolar RNA polymerase II drives ribosome biogenesis.
Abraham KJ, Khosraviani N, Chan JNY, Gorthi A, Samman A, Zhao DY, Wang M, Bokros M, Vidya E, Ostrowski LA, Oshidari R, Pietrobon V, Patel PS, Algouneh A, Singhania R, Liu Y, Yerlici VT, De Carvalho DD, Ohh M, Dickson BC, Hakem R, Greenblatt JF, Lee S, Bishop AJR, Mekhail K. Abraham KJ, et al. Among authors: chan jny. Nature. 2020 Sep;585(7824):298-302. doi: 10.1038/s41586-020-2497-0. Epub 2020 Jul 15. Nature. 2020. PMID: 32669707 Free PMC article.
SARS-CoV-2 targets ribosomal RNA biogenesis.
Yerlici VT, Astori A, Kejiou NS, Jordan CA, Khosraviani N, Chan JNY, Hakem R, Raught B, Palazzo AF, Mekhail K. Yerlici VT, et al. Among authors: chan jny. Cell Rep. 2024 Mar 26;43(3):113891. doi: 10.1016/j.celrep.2024.113891. Epub 2024 Feb 29. Cell Rep. 2024. PMID: 38427561 Free article.
Conserved Pbp1/Ataxin-2 regulates retrotransposon activity and connects polyglutamine expansion-driven protein aggregation to lifespan-controlling rDNA repeats.
Ostrowski LA, Hall AC, Szafranski KJ, Oshidari R, Abraham KJ, Chan JNY, Krustev C, Zhang K, Wang A, Liu Y, Guo R, Mekhail K. Ostrowski LA, et al. Among authors: chan jny. Commun Biol. 2018 Nov 5;1:187. doi: 10.1038/s42003-018-0187-3. eCollection 2018. Commun Biol. 2018. PMID: 30417124 Free PMC article.
14 results