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Single-Cell Analysis Reveals Unexpected Cellular Changes and Transposon Expression Signatures in the Colonic Epithelium of Treatment-Naïve Adult Crohn's Disease Patients.
Kanke M, Kennedy Ng MM, Connelly S, Singh M, Schaner M, Shanahan MT, Wolber EA, Beasley C, Lian G, Jain A, Long MD, Barnes EL, Herfarth HH, Isaacs KL, Hansen JJ, Kapadia M, Guillem JG, Feschotte C, Furey TS, Sheikh SZ, Sethupathy P. Kanke M, et al. Among authors: sheikh sz. Cell Mol Gastroenterol Hepatol. 2022;13(6):1717-1740. doi: 10.1016/j.jcmgh.2022.02.005. Epub 2022 Feb 12. Cell Mol Gastroenterol Hepatol. 2022. PMID: 35158099 Free PMC article.
Alterations to chromatin in intestinal macrophages link IL-10 deficiency to inappropriate inflammatory responses.
Simon JM, Davis JP, Lee SE, Schaner MR, Gipson GR, Weiser M, Sartor RB, Herfarth HH, Rahbar R, Sadiq TS, Koruda MJ, McGovern DP, Lieb JD, Mohlke KL, Furey TS, Sheikh SZ. Simon JM, et al. Among authors: sheikh sz. Eur J Immunol. 2016 Aug;46(8):1912-25. doi: 10.1002/eji.201546237. Epub 2016 Jun 1. Eur J Immunol. 2016. PMID: 27159132 Free PMC article.
Molecular classification of Crohn's disease reveals two clinically relevant subtypes.
Weiser M, Simon JM, Kochar B, Tovar A, Israel JW, Robinson A, Gipson GR, Schaner MS, Herfarth HH, Sartor RB, McGovern DPB, Rahbar R, Sadiq TS, Koruda MJ, Furey TS, Sheikh SZ. Weiser M, et al. Among authors: sheikh sz. Gut. 2018 Jan;67(1):36-42. doi: 10.1136/gutjnl-2016-312518. Epub 2016 Oct 14. Gut. 2018. PMID: 27742763 Free PMC article.
Colonic epithelial miR-31 associates with the development of Crohn's phenotypes.
Keith BP, Barrow JB, Toyonaga T, Kazgan N, O'Connor MH, Shah ND, Schaner MS, Wolber EA, Trad OK, Gipson GR, Pitman WA, Kanke M, Saxena SJ, Chaumont N, Sadiq TS, Koruda MJ, Cotney PA, Allbritton N, Trembath DG, Sylvester F, Furey TS, Sethupathy P, Sheikh SZ. Keith BP, et al. Among authors: sheikh sz. JCI Insight. 2018 Oct 4;3(19):e122788. doi: 10.1172/jci.insight.122788. JCI Insight. 2018. PMID: 30282822 Free PMC article.
Redefining the IBDs using genome-scale molecular phenotyping.
Furey TS, Sethupathy P, Sheikh SZ. Furey TS, et al. Among authors: sheikh sz. Nat Rev Gastroenterol Hepatol. 2019 May;16(5):296-311. doi: 10.1038/s41575-019-0118-x. Nat Rev Gastroenterol Hepatol. 2019. PMID: 30787446 Free PMC article. Review.
69 results