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Page 1
Exploring Scaffold Hopping for Novel 2-(Quinolin-4-yloxy)acetamides with Enhanced Antimycobacterial Activity.
Borsoi AF, Silva Ramos A, Sperotto N, Abbadi BL, Souza Macchi Hopf F, da Silva Dadda A, Scheibler Rambo R, Neves Muniz M, Delgado Paz J, Silveira Grams E, Fries da Silva F, Pissinate K, Galina L, Calle González L, Silva Duarte L, Alberton Perelló M, de Matos Czeczot A, Bizarro CV, Basso LA, Machado P. Borsoi AF, et al. Among authors: sperotto n. ACS Med Chem Lett. 2024 Mar 11;15(4):493-500. doi: 10.1021/acsmedchemlett.3c00570. eCollection 2024 Apr 11. ACS Med Chem Lett. 2024. PMID: 38628799
Antitubercular Activity of Novel 2-(Quinoline-4-yloxy)acetamides with Improved Drug-Like Properties.
Borsoi AF, Alice LM, Sperotto N, Ramos AS, Abbadi BL, Macchi Hopf FS, Silva Dadda AD, Rambo RS, Madeira Silva RB, Paz JD, Pissinate K, Muniz MN, Neves CE, Galina L, González LC, Perelló MA, de Matos Czeczot A, Leyser M, de Oliveira SD, de Araújo Lock G, de Araújo BV, Costa TD, Bizarro CV, Basso LA, Machado P. Borsoi AF, et al. Among authors: sperotto n. ACS Med Chem Lett. 2022 Jul 21;13(8):1337-1344. doi: 10.1021/acsmedchemlett.2c00254. eCollection 2022 Aug 11. ACS Med Chem Lett. 2022. PMID: 35978694 Free PMC article.
Evaluation of 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase (DAHPS) as a Vulnerable Target in Mycobacterium tuberculosis.
Galina L, Hopf FSM, Abbadi BL, Sperotto NDM, Czeczot AM, Duque-Villegas MA, Perello MA, Matter LB, de Souza EV, Parish T, Machado P, Basso LA, Bizarro CV. Galina L, et al. Among authors: sperotto ndm. Microbiol Spectr. 2022 Aug 31;10(4):e0072822. doi: 10.1128/spectrum.00728-22. Epub 2022 Jul 14. Microbiol Spectr. 2022. PMID: 35862980 Free PMC article.
Synthesis and Antimycobacterial Evaluation of N-(4-(Benzyloxy)benzyl)-4-aminoquinolines.
Grams ES, Silva Ramos A, Neves Muniz M, Rambo RS, Alberton Perelló M, Sperotto N, Calle González L, Duarte LS, Galina L, Silva Dadda A, Arraché Gonçalves G, Valim Bizarro C, Basso LA, Machado P. Grams ES, et al. Among authors: sperotto n. Molecules. 2022 Apr 15;27(8):2556. doi: 10.3390/molecules27082556. Molecules. 2022. PMID: 35458755 Free PMC article.
Short-chain fatty acid acetate triggers antiviral response mediated by RIG-I in cells from infants with respiratory syncytial virus bronchiolitis.
Antunes KH, Stein RT, Franceschina C, da Silva EF, de Freitas DN, Silveira J, Mocellin M, Leitão L, Fachi JL, Pral LP, Gonzalez A, Oliveira S, Duarte L, Cassão G, Gonçalves JIB, Reis TM, Abbadi BL, Dornelles M, Sperotto NDM, Rigo M, Rodrigues H, Jones M, Epifanio M, Guima S, Setubal JC, Jorge TR, Mansur DS, Mayer FQ, Varela APM, Bizarro CV, Machado P, Basso LA, Polack FP, Custovic A, Vinolo MAR, de Souza APD. Antunes KH, et al. Among authors: sperotto ndm. EBioMedicine. 2022 Mar;77:103891. doi: 10.1016/j.ebiom.2022.103891. Epub 2022 Feb 24. EBioMedicine. 2022. PMID: 35220042 Free PMC article.
Application of cellulosic materials as supports for single-step purification and immobilization of a recombinant β-galactosidase via cellulose-binding domain.
Gennari A, Simon R, Sperotto NDM, Bizarro CV, Basso LA, Machado P, Benvenutti EV, Renard G, Chies JM, Volpato G, Volken de Souza CF. Gennari A, et al. Among authors: sperotto ndm. Int J Biol Macromol. 2022 Feb 28;199:307-317. doi: 10.1016/j.ijbiomac.2022.01.006. Epub 2022 Jan 7. Int J Biol Macromol. 2022. PMID: 35007635
One-step purification of a recombinant beta-galactosidase using magnetic cellulose as a support: Rapid immobilization and high thermal stability.
Gennari A, Simon R, Sperotto NDM, Bizarro CV, Basso LA, Machado P, Benvenutti EV, Da Cas Viegas A, Nicolodi S, Renard G, Chies JM, Volpato G, Volken de Souza CF. Gennari A, et al. Among authors: sperotto ndm. Bioresour Technol. 2022 Feb;345:126497. doi: 10.1016/j.biortech.2021.126497. Epub 2021 Dec 6. Bioresour Technol. 2022. PMID: 34883192
Synthesis and Antimycobacterial Activity of 3-Phenyl-1H-indoles.
Jardim Etchart R, Rambo RS, Lopes Abbadi B, Sperotto N, Ev Neves C, Fries Silva F, Dornelles M, Duarte L, Souza Macchi F, Alberton Perelló M, Vescia Lourega R, Valim Bizarro C, Basso LA, Machado P. Jardim Etchart R, et al. Among authors: sperotto n. Molecules. 2021 Aug 25;26(17):5148. doi: 10.3390/molecules26175148. Molecules. 2021. PMID: 34500579 Free PMC article.
Targeting thymidine phosphorylase inhibition in human colorectal cancer xenografts.
Sperotto NDM, Silva RBM, Perelló MA, Borsoi AF, da Silva Dadda A, Roth CD, Freitas RDS, de Souza APD, Freitas DDN, Picada JN, de Sousa JT, Nabinger DD, Altenhofen S, Bonan CD, Rodrigues-Junior VS, Bizarro CV, Basso LA, Machado P. Sperotto NDM, et al. Biomed Pharmacother. 2021 Jul;139:111672. doi: 10.1016/j.biopha.2021.111672. Epub 2021 May 6. Biomed Pharmacother. 2021. PMID: 33965731 Free article.
25 results