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Early Emergence and Long-Term Persistence of HIV-Infected T-Cell Clones in Children.
Bale MJ, Katusiime MG, Wells D, Wu X, Spindler J, Halvas EK, Cyktor JC, Wiegand A, Shao W, Cotton MF, Hughes SH, Mellors JW, Coffin JM, Van Zyl GU, Kearney MF. Bale MJ, et al. Among authors: hughes sh. mBio. 2021 Apr 8;12(2):e00568-21. doi: 10.1128/mBio.00568-21. mBio. 2021. PMID: 33832973 Free PMC article.
Insertional activation of STAT3 and LCK by HIV-1 proviruses in T cell lymphomas.
Mellors JW, Guo S, Naqvi A, Brandt LD, Su L, Sun Z, Joseph KW, Demirov D, Halvas EK, Butcher D, Scott B, Hamilton A, Heil M, Karim B, Wu X, Hughes SH. Mellors JW, et al. Among authors: hughes sh. Sci Adv. 2021 Oct 15;7(42):eabi8795. doi: 10.1126/sciadv.abi8795. Epub 2021 Oct 13. Sci Adv. 2021. PMID: 34644108 Free PMC article.
HIV-1 viremia not suppressible by antiretroviral therapy can originate from large T cell clones producing infectious virus.
Halvas EK, Joseph KW, Brandt LD, Guo S, Sobolewski MD, Jacobs JL, Tumiotto C, Bui JK, Cyktor JC, Keele BF, Morse GD, Bale MJ, Shao W, Kearney MF, Coffin JM, Rausch JW, Wu X, Hughes SH, Mellors JW. Halvas EK, et al. Among authors: hughes sh. J Clin Invest. 2020 Nov 2;130(11):5847-5857. doi: 10.1172/JCI138099. J Clin Invest. 2020. PMID: 33016926 Free PMC article.
Integration in oncogenes plays only a minor role in determining the in vivo distribution of HIV integration sites before or during suppressive antiretroviral therapy.
Coffin JM, Bale MJ, Wells D, Guo S, Luke B, Zerbato JM, Sobolewski MD, Sia T, Shao W, Wu X, Maldarelli F, Kearney MF, Mellors JW, Hughes SH. Coffin JM, et al. Among authors: hughes sh. PLoS Pathog. 2021 Apr 7;17(4):e1009141. doi: 10.1371/journal.ppat.1009141. eCollection 2021 Apr. PLoS Pathog. 2021. PMID: 33826675 Free PMC article.
HIV-1 in lymph nodes is maintained by cellular proliferation during antiretroviral therapy.
McManus WR, Bale MJ, Spindler J, Wiegand A, Musick A, Patro SC, Sobolewski MD, Musick VK, Anderson EM, Cyktor JC, Halvas EK, Shao W, Wells D, Wu X, Keele BF, Milush JM, Hoh R, Mellors JW, Hughes SH, Deeks SG, Coffin JM, Kearney MF. McManus WR, et al. Among authors: hughes sh. J Clin Invest. 2019 Jul 30;129(11):4629-4642. doi: 10.1172/JCI126714. J Clin Invest. 2019. PMID: 31361603 Free PMC article. Clinical Trial.
385 results