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Characterization of structural, biochemical, pharmacokinetic, and pharmacodynamic properties of the LSD1 inhibitor bomedemstat in preclinical models.
Prostate. 2024 Apr 15. doi: 10.1002/pros.24707. Online ahead of print.
Prostate. 2024.
PMID: 38619005
LSD1 inhibition suppresses ASCL1 and de-represses YAP1 to drive potent activity against neuroendocrine prostate cancer.
Mandl A, Jasmine S, Krueger T, Kumar R, Coleman IM, Dalrymple SL, Antony L, Rosen DM, Jing Y, Hanratty B, Patel RA, Jin-Yih L, Dias J, Celatka CA, Tapper AE, Kleppe M, Kanayama M, Speranzini V, Wang YZ, Luo J, Corey E, Sena LA, Casero RA, Lotan T, Trock BJ, Kachhap SK, Denmeade SR, Carducci MA, Mattevi A, Haffner MC, Nelson PS, Rienhoff HY, Isaacs JT, Brennen WN.
Mandl A, et al. Among authors: tapper ae.
bioRxiv [Preprint]. 2024 Jan 22:2024.01.17.576106. doi: 10.1101/2024.01.17.576106.
bioRxiv. 2024.
PMID: 38328141
Free PMC article.
Preprint.
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A phase 1 dose-escalation study: safety, tolerability, and pharmacokinetics of FBS0701, a novel oral iron chelator for the treatment of transfusional iron overload.
Rienhoff HY Jr, Viprakasit V, Tay L, Harmatz P, Vichinsky E, Chirnomas D, Kwiatkowski JL, Tapper A, Kramer W, Porter JB, Neufeld EJ.
Rienhoff HY Jr, et al.
Haematologica. 2011 Apr;96(4):521-5. doi: 10.3324/haematol.2010.034405. Epub 2010 Dec 20.
Haematologica. 2011.
PMID: 21173101
Free PMC article.
Clinical Trial.
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The gif paradox.
Stavropoulos P, Celenligil-Cetin R, Tapper AE.
Stavropoulos P, et al. Among authors: tapper ae.
Acc Chem Res. 2001 Sep;34(9):745-52. doi: 10.1021/ar000100+.
Acc Chem Res. 2001.
PMID: 11560474
Review.
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Oxygenation of Hydrocarbons Mediated by Mixed-Valent Basic Iron Trifluoroacetate and Valence-Separated Component Species under Gif-Type Conditions Involves Carbon- and Oxygen-Centered Radicals This work was supported by the U.S. Environmental Protection Agency and the NIH/NIEHS (superfund).
Tapper AE, Long JR, Staples RJ, Stavropoulos P.
Tapper AE, et al.
Angew Chem Int Ed Engl. 2000 Jul 3;39(13):2343-2346. doi: 10.1002/1521-3773(20000703)39:13<2343::aid-anie2343>3.0.co;2-t.
Angew Chem Int Ed Engl. 2000.
PMID: 10941085
No abstract available.
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