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Macrophages control pathological interferon responses during viral respiratory infection.
Hoagland DA, Rodríguez-Morales P, Mann AO, Yu S, Lai A, Vazquez AB, Pope SD, Lim J, Li S, Zhang X, Li MO, Medzhitov R, Franklin RA. Hoagland DA, et al. Among authors: franklin ra. bioRxiv [Preprint]. 2023 Dec 17:2023.12.16.572019. doi: 10.1101/2023.12.16.572019. bioRxiv. 2023. PMID: 38168230 Free PMC article. Preprint.
Tumor-associated macrophages expressing the transcription factor IRF8 promote T cell exhaustion in cancer.
Nixon BG, Kuo F, Ji L, Liu M, Capistrano K, Do M, Franklin RA, Wu X, Kansler ER, Srivastava RM, Purohit TA, Sanchez A, Vuong L, Krishna C, Wang X, Morse Iii HC, Hsieh JJ, Chan TA, Murphy KM, Moon JJ, Hakimi AA, Li MO. Nixon BG, et al. Among authors: franklin ra. Immunity. 2022 Nov 8;55(11):2044-2058.e5. doi: 10.1016/j.immuni.2022.10.002. Epub 2022 Oct 25. Immunity. 2022. PMID: 36288724 Free PMC article.
Microenvironmental sensing by fibroblasts controls macrophage population size.
Zhou X, Franklin RA, Adler M, Carter TS, Condiff E, Adams TS, Pope SD, Philip NH, Meizlish ML, Kaminski N, Medzhitov R. Zhou X, et al. Among authors: franklin ra. Proc Natl Acad Sci U S A. 2022 Aug 9;119(32):e2205360119. doi: 10.1073/pnas.2205360119. Epub 2022 Aug 5. Proc Natl Acad Sci U S A. 2022. PMID: 35930670 Free PMC article.
Wild type and gain of function mutant TP53 can regulate the sensitivity of pancreatic cancer cells to chemotherapeutic drugs, EGFR/Ras/Raf/MEK, and PI3K/mTORC1/GSK-3 pathway inhibitors, nutraceuticals and alter metabolic properties.
McCubrey JA, Meher AK, Akula SM, Abrams SL, Steelman LS, LaHair MM, Franklin RA, Martelli AM, Ratti S, Cocco L, Barbaro F, Duda P, Gizak A. McCubrey JA, et al. Among authors: franklin ra. Aging (Albany NY). 2022 Apr 27;14(8):3365-3386. doi: 10.18632/aging.204038. Epub 2022 Apr 27. Aging (Albany NY). 2022. PMID: 35477123 Free PMC article.
Tissue Homeostasis and Inflammation.
Meizlish ML, Franklin RA, Zhou X, Medzhitov R. Meizlish ML, et al. Among authors: franklin ra. Annu Rev Immunol. 2021 Apr 26;39:557-581. doi: 10.1146/annurev-immunol-061020-053734. Epub 2021 Mar 2. Annu Rev Immunol. 2021. PMID: 33651964
167 results