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Nuclear GAPDH in cortical microglia mediates cellular stress-induced cognitive inflexibility.
Ramos A, Ishizuka K, Hayashida A, Namkung H, Hayes LN, Srivastava R, Zhang M, Kariya T, Elkins N, Palen T, Carloni E, Tsujimura T, Calva C, Ikemoto S, Rais R, Slusher BS, Niwa M, Saito A, Saitoh T, Takimoto E, Sawa A. Ramos A, et al. Among authors: zhang m. Mol Psychiatry. 2024 Apr 13. doi: 10.1038/s41380-024-02553-1. Online ahead of print. Mol Psychiatry. 2024. PMID: 38615102
The mitochondrial regulator PGC1α is induced by cGMP-PKG signaling and mediates the protective effects of phosphodiesterase 5 inhibition in heart failure.
Zhu G, Ueda K, Hashimoto M, Zhang M, Sasaki M, Kariya T, Sasaki H, Kaludercic N, Lee DI, Bedja D, Gabrielson M, Yuan Y, Paolocci N, Blanton RM, Karas RH, Mendelsohn ME, O'Rourke B, Kass DA, Takimoto E. Zhu G, et al. Among authors: zhang m. FEBS Lett. 2022 Jan;596(1):17-28. doi: 10.1002/1873-3468.14228. Epub 2021 Nov 19. FEBS Lett. 2022. PMID: 34778969 Free PMC article.
Cyclic GMP/PKG-dependent inhibition of TRPC6 channel activity and expression negatively regulates cardiomyocyte NFAT activation Novel mechanism of cardiac stress modulation by PDE5 inhibition.
Koitabashi N, Aiba T, Hesketh GG, Rowell J, Zhang M, Takimoto E, Tomaselli GF, Kass DA. Koitabashi N, et al. Among authors: zhang m. J Mol Cell Cardiol. 2010 Apr;48(4):713-24. doi: 10.1016/j.yjmcc.2009.11.015. Epub 2009 Dec 1. J Mol Cell Cardiol. 2010. PMID: 19961855 Free PMC article.
Sildenafil stops progressive chamber, cellular, and molecular remodeling and improves calcium handling and function in hearts with pre-existing advanced hypertrophy caused by pressure overload.
Nagayama T, Hsu S, Zhang M, Koitabashi N, Bedja D, Gabrielson KL, Takimoto E, Kass DA. Nagayama T, et al. Among authors: zhang m. J Am Coll Cardiol. 2009 Jan 13;53(2):207-15. doi: 10.1016/j.jacc.2008.08.069. J Am Coll Cardiol. 2009. PMID: 19130990 Free PMC article.
Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice.
Takimoto E, Koitabashi N, Hsu S, Ketner EA, Zhang M, Nagayama T, Bedja D, Gabrielson KL, Blanton R, Siderovski DP, Mendelsohn ME, Kass DA. Takimoto E, et al. Among authors: zhang m. J Clin Invest. 2009 Feb;119(2):408-20. doi: 10.1172/JCI35620. Epub 2009 Jan 5. J Clin Invest. 2009. PMID: 19127022 Free PMC article.
57,346 results
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