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A Mettl16/m6A/mybl2b/Igf2bp1 axis ensures cell cycle progression of embryonic hematopoietic stem and progenitor cells.
Han Y, Sun K, Yu S, Qin Y, Zhang Z, Luo J, Hu H, Dai L, Cui M, Jiang C, Liu F, Huang Y, Gao P, Chen X, Xin T, Ren X, Wu X, Song J, Wang Q, Tang Z, Chen J, Zhang H, Zhang X, Liu M, Luo D. Han Y, et al. Among authors: chen j, chen x. EMBO J. 2024 May;43(10):1990-2014. doi: 10.1038/s44318-024-00082-9. Epub 2024 Apr 11. EMBO J. 2024. PMID: 38605226 Free PMC article.
N(6)-methyladenosine-binding protein YTHDF1 suppresses EBV replication and promotes EBV RNA decay.
Xia TL, Li X, Wang X, Zhu YJ, Zhang H, Cheng W, Chen ML, Ye Y, Li Y, Zhang A, Dai DL, Zhu QY, Yuan L, Zheng J, Huang H, Chen SQ, Xiao ZW, Wang HB, Roy G, Zhong Q, Lin D, Zeng YX, Wang J, Zhao B, Gewurz BE, Chen J, Zuo Z, Zeng MS. Xia TL, et al. Among authors: chen j, chen sq, chen ml. EMBO Rep. 2021 Apr 7;22(4):e50128. doi: 10.15252/embr.202050128. Epub 2021 Feb 19. EMBO Rep. 2021. PMID: 33605073 Free PMC article.
METTL16 drives leukemogenesis and leukemia stem cell self-renewal by reprogramming BCAA metabolism.
Han L, Dong L, Leung K, Zhao Z, Li Y, Gao L, Chen Z, Xue J, Qing Y, Li W, Pokharel SP, Gao M, Chen M, Shen C, Tan B, Small A, Wang K, Zhang Z, Qin X, Yang L, Wunderlich M, Zhang B, Mulloy JC, Marcucci G, Chen CW, Wei M, Su R, Chen J, Deng X. Han L, et al. Among authors: chen z, chen j, chen m, chen cw. Cell Stem Cell. 2023 Jan 5;30(1):52-68.e13. doi: 10.1016/j.stem.2022.12.006. Cell Stem Cell. 2023. PMID: 36608679 Free PMC article.
METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m6A Modification.
Weng H, Huang H, Wu H, Qin X, Zhao BS, Dong L, Shi H, Skibbe J, Shen C, Hu C, Sheng Y, Wang Y, Wunderlich M, Zhang B, Dore LC, Su R, Deng X, Ferchen K, Li C, Sun M, Lu Z, Jiang X, Marcucci G, Mulloy JC, Yang J, Qian Z, Wei M, He C, Chen J. Weng H, et al. Among authors: chen j. Cell Stem Cell. 2018 Feb 1;22(2):191-205.e9. doi: 10.1016/j.stem.2017.11.016. Epub 2017 Dec 28. Cell Stem Cell. 2018. PMID: 29290617 Free PMC article.
The Biogenesis and Precise Control of RNA m6A Methylation.
Huang H, Weng H, Chen J. Huang H, et al. Among authors: chen j. Trends Genet. 2020 Jan;36(1):44-52. doi: 10.1016/j.tig.2019.10.011. Epub 2019 Dec 4. Trends Genet. 2020. PMID: 31810533 Free PMC article. Review.
METTL16 exerts an m6A-independent function to facilitate translation and tumorigenesis.
Su R, Dong L, Li Y, Gao M, He PC, Liu W, Wei J, Zhao Z, Gao L, Han L, Deng X, Li C, Prince E, Tan B, Qing Y, Qin X, Shen C, Xue M, Zhou K, Chen Z, Xue J, Li W, Qin H, Wu X, Sun M, Nam Y, Chen CW, Huang W, Horne D, Rosen ST, He C, Chen J. Su R, et al. Among authors: chen z, chen j, chen cw. Nat Cell Biol. 2022 Feb;24(2):205-216. doi: 10.1038/s41556-021-00835-2. Epub 2022 Feb 10. Nat Cell Biol. 2022. PMID: 35145225 Free PMC article.
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