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Coronary Artery Disease Risk Variant Dampens the Expression of CALCRL by Reducing HSF Binding to Shear Stress Responsive Enhancer in Endothelial Cells In Vitro.
Selvarajan I, Kiema M, Huang RT, Li J, Zhu J, Pölönen P, Örd T, Õunap K, Godiwala M, Golebiewski AK, Ravindran A, Mäklin K, Toropainen A, Stolze LK, Arce M, Magnusson PU, White S, Romanoski CE, Heinäniemi M, Laakkonen JP, Fang Y, Kaikkonen MU. Selvarajan I, et al. Among authors: romanoski ce. Arterioscler Thromb Vasc Biol. 2024 Jun;44(6):1330-1345. doi: 10.1161/ATVBAHA.123.318964. Epub 2024 Apr 11. Arterioscler Thromb Vasc Biol. 2024. PMID: 38602103 Free article.
Genetic variant at coronary artery disease and ischemic stroke locus 1p32.2 regulates endothelial responses to hemodynamics.
Krause MD, Huang RT, Wu D, Shentu TP, Harrison DL, Whalen MB, Stolze LK, Di Rienzo A, Moskowitz IP, Civelek M, Romanoski CE, Fang Y. Krause MD, et al. Among authors: romanoski ce. Proc Natl Acad Sci U S A. 2018 Nov 27;115(48):E11349-E11358. doi: 10.1073/pnas.1810568115. Epub 2018 Nov 14. Proc Natl Acad Sci U S A. 2018. PMID: 30429326 Free PMC article.
Systems Genetics in Human Endothelial Cells Identifies Non-coding Variants Modifying Enhancers, Expression, and Complex Disease Traits.
Stolze LK, Conklin AC, Whalen MB, López Rodríguez M, Õunap K, Selvarajan I, Toropainen A, Örd T, Li J, Eshghi A, Solomon AE, Fang Y, Kaikkonen MU, Romanoski CE. Stolze LK, et al. Among authors: romanoski ce. Am J Hum Genet. 2020 Jun 4;106(6):748-763. doi: 10.1016/j.ajhg.2020.04.008. Epub 2020 May 21. Am J Hum Genet. 2020. PMID: 32442411 Free PMC article.
Integrative analysis of liver-specific non-coding regulatory SNPs associated with the risk of coronary artery disease.
Selvarajan I, Toropainen A, Garske KM, López Rodríguez M, Ko A, Miao Z, Kaminska D, Õunap K, Örd T, Ravindran A, Liu OH, Moreau PR, Jawahar Deen A, Männistö V, Pan C, Levonen AL, Lusis AJ, Heikkinen S, Romanoski CE, Pihlajamäki J, Pajukanta P, Kaikkonen MU. Selvarajan I, et al. Among authors: romanoski ce. Am J Hum Genet. 2021 Mar 4;108(3):411-430. doi: 10.1016/j.ajhg.2021.02.006. Epub 2021 Feb 23. Am J Hum Genet. 2021. PMID: 33626337 Free PMC article.
Single cell 'omic profiles of human aortic endothelial cells in vitro and human atherosclerotic lesions ex vivo reveals heterogeneity of endothelial subtype and response to activating perturbations.
Adelus ML, Ding J, Tran BT, Conklin AC, Golebiewski AK, Stolze LK, Whalen MB, Cusanovich DA, Romanoski CE. Adelus ML, et al. Among authors: romanoski ce. bioRxiv [Preprint]. 2024 Jan 17:2023.04.03.535495. doi: 10.1101/2023.04.03.535495. bioRxiv. 2024. PMID: 37066416 Free PMC article. Updated. Preprint.
Single-Cell Epigenomics and Functional Fine-Mapping of Atherosclerosis GWAS Loci.
Örd T, Õunap K, Stolze LK, Aherrahrou R, Nurminen V, Toropainen A, Selvarajan I, Lönnberg T, Aavik E, Ylä-Herttuala S, Civelek M, Romanoski CE, Kaikkonen MU. Örd T, et al. Among authors: romanoski ce. Circ Res. 2021 Jul 9;129(2):240-258. doi: 10.1161/CIRCRESAHA.121.318971. Epub 2021 May 24. Circ Res. 2021. PMID: 34024118 Free PMC article.
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