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Coronary Artery Disease Risk Variant Dampens the Expression of CALCRL by Reducing HSF Binding to Shear Stress Responsive Enhancer in Endothelial Cells In Vitro.
Selvarajan I, Kiema M, Huang RT, Li J, Zhu J, Pölönen P, Örd T, Õunap K, Godiwala M, Golebiewski AK, Ravindran A, Mäklin K, Toropainen A, Stolze LK, Arce M, Magnusson PU, White S, Romanoski CE, Heinäniemi M, Laakkonen JP, Fang Y, Kaikkonen MU. Selvarajan I, et al. Among authors: maklin k. Arterioscler Thromb Vasc Biol. 2024 Jun;44(6):1330-1345. doi: 10.1161/ATVBAHA.123.318964. Epub 2024 Apr 11. Arterioscler Thromb Vasc Biol. 2024. PMID: 38602103 Free article.
Evaluation of FASN inhibitors by a versatile toolkit reveals differences in pharmacology between human and rodent FASN preparations and in antiproliferative efficacy in vitro vs. in situ in human cancer cells.
Singha PK, Mäklin K, Vihavainen T, Laitinen T, Nevalainen TJ, Patil MR, Tonduru AK, Poso A, Laitinen JT, Savinainen JR. Singha PK, et al. Among authors: maklin k. Eur J Pharm Sci. 2020 Apr 7;149:105321. doi: 10.1016/j.ejps.2020.105321. Online ahead of print. Eur J Pharm Sci. 2020. PMID: 32275951